Zhong Yamei, Chen Lin, Yu Shiping, Yang Yongzhen, Liu Xuguang
Key Laboratory of Interface Science and Engineering in Advanced Materials, Ministry of Education, Taiyuan University of Technology, Taiyuan 030024, China.
Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering, Taiyuan 030032, China.
ACS Biomater Sci Eng. 2023 Dec 11;9(12):6548-6566. doi: 10.1021/acsbiomaterials.3c00988. Epub 2023 Nov 9.
Theranostics technology that combines tumor diagnosis or monitoring with therapy is an important direction for the future development of tumor treatment. It takes advantage of efficiently observing tumor tissues, monitoring tumor treatment in real time, and significantly improving the cure efficiency. Magnetic carbon dots (CDs) are of wide interest as molecular imaging probes, drug carriers, photosensitizers, and radiosensitizers in the integration of tumor fluorescence/magnetic resonance bimodal diagnosis and treatment because of their small size, good optical stability, magnetic relaxation rate, and biocompatibility. This review first analyzes and compares the synthesis methods and physicochemical properties of magnetic CDs in recent years and then concludes their mechanism in tumor fluorescence/magnetic resonance bimodal imaging and therapy in details. Subsequently, the research progress of their application in tumor theranostics are summarized. Finally, the problems and challenges of magnetic CDs for development at this stage are prospected. This review provides new ideas for their controlled synthesis and application in efficient and precise therapy for tumors.
将肿瘤诊断或监测与治疗相结合的诊疗技术是肿瘤治疗未来发展的一个重要方向。它有利于高效观察肿瘤组织、实时监测肿瘤治疗情况，并显著提高治愈效率。磁性碳点（CDs）因其尺寸小、光学稳定性好、磁弛豫率高和生物相容性好，在肿瘤荧光/磁共振双模态诊断与治疗一体化中作为分子成像探针、药物载体、光敏剂和放射增敏剂受到广泛关注。本文综述首先分析比较了近年来磁性碳点的合成方法和理化性质，然后详细总结了它们在肿瘤荧光/磁共振双模态成像和治疗中的作用机制。随后，总结了它们在肿瘤诊疗中的应用研究进展。最后，展望了现阶段磁性碳点发展面临的问题与挑战。本综述为其可控合成及其在肿瘤高效精准治疗中的应用提供了新思路。
