Moreno C, Esdaile J
Eur J Immunol. 1983 Mar;13(3):262-4. doi: 10.1002/eji.1830130317.
Murine antisera specific for the alpha (1 leads to 3) and alpha (1 leads to 6)-linked glucosyl determinants of dextran, as well as for meningococcal polysaccharide group C, have been examined for the distribution of their immunoglobulin classes and subclasses. Whereas the thymus-independent anti-alpha (1 leads to 3) dextran response in BALB/c mice was found to be IgM greater than IgG3 greater than IgA, thus corresponding to previously published work, neither the alpha (1 leads to 6) response in its thymus-dependent or-independent form, nor the response to purified meningococcal polysaccharide, corresponded to this pattern. No preference for any of the IgG subclasses appeared for these antigens when given as thymus-independent carbohydrates. On the other hand, thymus-dependent forms of alpha (1 leads to 6) dextran showed an IgG1 greater than IgG3 greater than IgG2 pattern.
已经对针对葡聚糖的α（1→3）和α（1→6）连接的葡糖基决定簇以及脑膜炎球菌C群多糖的鼠抗血清进行了免疫球蛋白类别和亚类分布的检测。虽然在BALB/c小鼠中发现非胸腺依赖性抗α（1→3）葡聚糖反应中IgM大于IgG3大于IgA，这与先前发表的研究结果一致，但无论是胸腺依赖性还是非胸腺依赖性形式的α（1→6）反应，以及对纯化的脑膜炎球菌多糖的反应，均不符合这种模式。当作为非胸腺依赖性碳水化合物给予时，这些抗原对任何IgG亚类均无偏好。另一方面，胸腺依赖性形式的α（1→6）葡聚糖呈现出IgG1大于IgG3大于IgG2的模式。
