病毒诱导的小鼠IgG抗体亚类的调节
Virally induced modulation of murine IgG antibody subclasses.
作者信息
Coutelier J P, van der Logt J T, Heessen F W, Vink A, van Snick J
机构信息
Unit of Experimental Medicine, Université Catholique de Louvain, Bruxelles, Belgium.
出版信息
J Exp Med. 1988 Dec 1;168(6):2373-8. doi: 10.1084/jem.168.6.2373.
Abstract
The isotypic distribution of murine IgG was examined after infection with several viruses. The results indicate that when a hypergammaglobulinemia was induced by the infection, it was restricted to the IgG2a and, to a lesser extent, to the IgG2b subclasses. In addition, when mice were infected with some viruses concomitantly with the immunization with a soluble protein antigen, a modification in the isotypic distribution of antiprotein antibodies was observed, with a preferential production of IgG2a. These observations indicate that viral infections can actively influence the switch of Igs and selectively stimulate the production of the IgG2a subclass.
摘要
在感染几种病毒后，对小鼠IgG的同型分布进行了检测。结果表明，当感染诱导产生高丙种球蛋白血症时，其仅限于IgG2a，在较小程度上还涉及IgG2b亚类。此外，当小鼠在接种可溶性蛋白抗原的同时感染某些病毒时，观察到抗蛋白抗体的同型分布发生改变，优先产生IgG2a。这些观察结果表明，病毒感染可积极影响免疫球蛋白的转换，并选择性地刺激IgG2a亚类的产生。
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