白皮杉醇型二萜类化合物从. 的假种皮中得到。
Abietane-Type Diterpenoids from the Arils of .
机构信息
College of Food Science and Technology, Northwest University, Xi'an 710075, China.
Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China.
出版信息
Molecules. 2024 Apr 23;29(9):1905. doi: 10.3390/molecules29091905.
A chemical investigation of the arils of led to the isolation of seven abietane-type diterpenoids (compounds -) including three previously undescribed compounds, one unreported natural product, and three known analogs. The structures of these compounds were determined by means of spectroscopy, single-crystal X-ray diffraction, and ECD spectra. An antibacterial activity assay showed that compounds and had significant inhibitory effects on methicillin-resistant , with MIC values of 100 μM. Moreover, compounds , , , and exhibited anti-neuroinflammatory activity in LPS-stimulated BV-2 microglia cells, with the IC values ranging from 38.4 to 67.9 μM.
对 led 的种皮进行化学研究，分离得到了 7 个松香烷型二萜（化合物 -），包括 3 个以前未描述的化合物、1 个未报道的天然产物和 3 个已知的类似物。这些化合物的结构通过光谱、单晶 X 射线衍射和 ECD 光谱确定。抗菌活性测定表明，化合物 和 对耐甲氧西林金黄色葡萄球菌具有显著的抑制作用，MIC 值为 100 μM。此外，化合物 、 、 、和 在 LPS 刺激的 BV-2 小胶质细胞中表现出抗神经炎症活性，IC 值范围为 38.4 至 67.9 μM。
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