Macartney J C, Camplejohn R S
J Pathol. 1986 Oct;150(2):113-8. doi: 10.1002/path.1711500205.
DNA flow cytometry has been carried out on histologically processed human gastric tissue showing varying grades of gastric dysplasia, intramucosal carcinoma and regenerative changes. No cases of DNA aneuploidy were encountered in cases showing regenerative changes or mild or moderate dysplasia. DNA aneuploidy was found in 5/7 cases of severe dysplasia and 3/11 cases of intramucosal cancer. Irregularities of the G0/G1 peak were encountered in a further 18 samples including normal and regenerative gastric mucosa. However these were not thought to indicate DNA aneuploidy. The interpretation of these abnormalities and the affect on the frequency with which DNA aneuploidy is reported in pathological lesions is discussed.
已对经组织学处理的人胃组织进行DNA流式细胞术检测，这些胃组织呈现出不同程度的胃发育异常、黏膜内癌和再生性改变。在呈现再生性改变或轻度或中度发育异常的病例中，未发现DNA非整倍体情况。在7例重度发育异常病例中有5例以及11例黏膜内癌病例中有3例发现了DNA非整倍体。在另外18个样本（包括正常和再生性胃黏膜）中遇到了G0/G1峰不规则的情况。然而，这些情况被认为并不表明存在DNA非整倍体。本文讨论了这些异常情况的解读以及对病理病变中报道的DNA非整倍体频率的影响。
