Center for Integrative & Cognitive Neuroscience, Vanderbilt Vision Research Center, Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA; Department of Psychology, The University of the South, Sewanee, TN 37383, USA.
Center for Integrative & Cognitive Neuroscience, Vanderbilt Vision Research Center, Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA.
Cell Rep. 2023 Nov 28;42(11):113422. doi: 10.1016/j.celrep.2023.113422. Epub 2023 Nov 10.
The medial frontal cortex (MFC) plays an important but disputed role in speed-accuracy trade-off (SAT). In samples of neural spiking in the supplementary eye field (SEF) in the MFC simultaneous with the visuomotor frontal eye field and superior colliculus in macaques performing a visual search with instructed SAT, during accuracy emphasis, most SEF neurons discharge less from before stimulus presentation until response generation. Discharge rates adjust immediately and simultaneously across structures upon SAT cue changes. SEF neurons signal choice errors with stronger and earlier activity during accuracy emphasis. Other neurons signal timing errors, covarying with adjusting response time. Spike correlations between neurons in the SEF and visuomotor areas did not appear, disappear, or change sign across SAT conditions or trial outcomes. These results clarify findings with noninvasive measures, complement previous neurophysiological findings, and endorse the role of the MFC as a critic for the actor instantiated in visuomotor structures.
内侧额皮质（MFC）在速度准确性权衡（SAT）中发挥着重要但有争议的作用。在猕猴执行视觉搜索并受到 SAT 指令的情况下，与视觉运动额眼区和上丘同时记录 MFC 中的补充眼区（SEF）中的神经尖峰样本中，在强调准确性时，大多数 SEF 神经元在刺激呈现前到反应生成期间的放电量减少。放电率在 SAT 线索变化时立即并在结构之间进行调整。在强调准确性时，SEF 神经元通过更强和更早的活动来发出选择错误信号。其他神经元发出与调整反应时间相关的定时错误信号。SEF 神经元与视觉运动区之间的尖峰相关性在 SAT 条件或试验结果下并未出现、消失或改变符号。这些结果阐明了非侵入性测量的发现，补充了以前的神经生理学发现，并支持 MFC 作为在视觉运动结构中体现的演员的批评者的作用。
