Mani R, Gorman F W, White J E
J R Soc Med. 1986 Nov;79(11):650-4. doi: 10.1177/014107688607901111.
Using skin-surface sensors, transcutaneous oxygen tension (TcPo2) has been measured at the edges of ulcers and at control sites proximal to wounds on the same legs. TcPo2 at 43 degrees C at the edges of venous ulcers was found to be significantly different (P less than 0.003) from that of arterial and mixed arteriovenous ulcers (P less than 0.05) respectively. TcPo2 on healed skin was higher than at any wound edge. At this temperature TcPo2 was also found to be significantly different (P less than 0.001) on the intact skin of patients with venous disease when compared with measurements at identical sites on healthy controls. In the same group, these TcPo2 values increased with dependency. By contrast, at 37 degrees C TcPo2 was no different between groups (P less than 0.10), nor did it alter with position. This protocol adopted for investigating ulcers enables a quantitative distinction to be made between ulcers of different aetiologies. The differences in TcPo2 between different ulcers and healed skin support the fibrin cuff mechanism which has been suggested as the cause of venous ulceration.
利用皮肤表面传感器，已在溃疡边缘以及同一条腿上伤口近端的对照部位测量了经皮氧分压（TcPo2）。发现静脉性溃疡边缘在43摄氏度时的TcPo2与动脉性溃疡和动静脉混合型溃疡的TcPo2分别存在显著差异（P<0.003）（P<0.05）。愈合皮肤上的TcPo2高于任何伤口边缘处的TcPo2。在此温度下，与健康对照者相同部位的测量值相比，静脉疾病患者完整皮肤上的TcPo2也存在显著差异（P<0.001）。在同一组中，这些TcPo2值随体位改变而升高。相比之下，在37摄氏度时，各组之间的TcPo2没有差异（P<0.10），也不随体位改变。该用于研究溃疡的方案能够对不同病因的溃疡进行定量区分。不同溃疡与愈合皮肤之间TcPo2的差异支持了已被提出作为静脉溃疡病因的纤维蛋白袖套机制。
