Numamoto Hitomi, Fujimoto Koji, Miyake Kanae Kawai, Fushimi Yasutaka, Okuchi Sachi, Imai Rimika, Kondo Hiroki, Saga Tsuneo, Nakamoto Yuji
Department of Advanced Imaging in Medical Magnetic Resonance, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan.
Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan.
Magn Reson Med Sci. 2025 Jan 1;24(1):66-77. doi: 10.2463/mrms.mp.2023-0102. Epub 2023 Nov 10.
To compare image distortion and reproducibility of quantitative values between reverse encoding distortion correction (RDC) diffusion-weighted imaging (DWI) and conventional DWI techniques in a phantom study and in healthy volunteers.
This prospective study was conducted with the approval of our institutional review board. Written informed consent was obtained from each participant. RDC-DWIs were created from images obtained at 3T in three orthogonal directions in a phantom and in 10 participants (mean age, 70.9 years; age range, 63-83 years). Images without distortion correction (noDC-DWI) and those corrected with B0 (B0c-DWI) were also created. To evaluate distortion, coefficients of variation were calculated for each voxel and ROIs were placed at four levels of the brain. To evaluate the reproducibility of apparent diffusion coefficient (ADC) measurements, intra- and inter-scan variability (%CV) were calculated from repeated scans of the phantom. Analysis was performed using Wilcoxon signed-rank test with Bonferroni correction, and P < 0.05 was considered statistically significant.
In the phantom, distortion was less in RDC-DWI than in B0c-DWI (P < 0.006), and was less in B0c-DWI than in noDC-DWI (P < 0.006). Intra-scan %CV was within 1.30%, and inter-scan %CV was within 2.99%. In the volunteers, distortion was less in RDC-DWI than in B0c-DWI in three of four locations (P < 0.006), and was less in B0c-DWI than in noDC-DWI (P < 0.006). At the middle cerebellar peduncle, distortion was less in RDC-DWI than in noDC-DWI (P < 0.006), and was less in noDC-DWI than in B0c-DWI (P < 0.0177).
In both the phantom and in volunteers, distortion was the least in RDC-DWI than in B0c-DWI and noDC-DWI.
在体模研究和健康志愿者中比较反向编码失真校正（RDC）扩散加权成像（DWI）与传统DWI技术之间的图像失真和定量值的可重复性。
本前瞻性研究经机构审查委员会批准进行。获得了每位参与者的书面知情同意书。在体模以及10名参与者（平均年龄70.9岁；年龄范围63 - 83岁）中，从3T下在三个正交方向获取的图像创建RDC - DWI。还创建了未进行失真校正的图像（noDC - DWI）以及用B0校正的图像（B0c - DWI）。为了评估失真，计算每个体素的变异系数，并在大脑的四个层面放置感兴趣区（ROI）。为了评估表观扩散系数（ADC）测量的可重复性，从体模的重复扫描中计算扫描内和扫描间的变异性（%CV）。使用带有Bonferroni校正的Wilcoxon符号秩检验进行分析，P < 0.05被认为具有统计学意义。
在体模中，RDC - DWI的失真小于B0c - DWI（P < 0.006），且Boc - DWI的失真小于noDC - DWI（P < 0.006）。扫描内%CV在1.30%以内，扫描间%CV在2.99%以内。在志愿者中，在四个位置中的三个位置，RDC - DWI的失真小于B0c - DWI（P < 0.006），且B0c - DWI的失真小于noDC - DWI（P < 0.006）。在小脑中脚处，RDC - DWI的失真小于noDC - DWI（P < 0.006），且noDC - DWI的失真小于B0c - DWI（P < 0.0177）。
在体模和志愿者中，RDC - DWI的失真均小于B0c - DWI和noDC - DWI。
