Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Institutes for Translational Medicine, State Key Laboratory of Radiation Medicine and Protection, The First Affiliated Hospital of Soochow University, Suzhou Medical College of Soochow University, China.
Mol Oncol. 2024 Sep;18(9):2087-2106. doi: 10.1002/1878-0261.13551. Epub 2024 Mar 21.
Hyaluronic acid (HA) is a major component of the extracellular matrix, providing essential mechanical scaffolding for cells and, at the same time, mediating essential biochemical signals required for tissue homeostasis. Many solid tumors are characterized by dysregulated HA metabolism, resulting in increased HA levels in cancer tissues. HA interacts with several cell surface receptors, such as cluster of differentiation 44 and receptor for hyaluronan-mediated motility, thus co-regulating important signaling pathways in cancer development and progression. In this review, we describe the enzymes controlling HA metabolism and its intracellular effectors emphasizing their impact on cancer chemotherapy resistance. We will also explore the current and future prospects of HA-based therapy, highlighting the opportunities and challenges in the field.
透明质酸（HA）是细胞外基质的主要成分，为细胞提供必需的机械支架，同时介导组织平衡所需的重要生化信号。许多实体瘤的特征是透明质酸代谢失调，导致癌组织中透明质酸水平升高。透明质酸与几种细胞表面受体相互作用，如 CD44 和透明质酸介导的运动受体，从而共同调节癌症发展和进展中的重要信号通路。在这篇综述中，我们描述了控制透明质酸代谢的酶及其细胞内效应物，强调了它们对癌症化疗耐药性的影响。我们还将探讨基于透明质酸的治疗的现状和未来前景，突出该领域的机遇和挑战。
