Bao Xunxia, Ran Juan, Kong Chuifang, Wan Zunxi, Wang Juling, Yu Tengfei, Ruan Shengming, Ding Wenjing, Xia Leiming, Zhang Daoxiang
School of Life Sciences, Anhui Medical University, Hefei, 230032, China.
School of Life Sciences, Northeast Normal University, Changchun, 130024, China.
Heliyon. 2023 Aug 12;9(8):e19112. doi: 10.1016/j.heliyon.2023.e19112. eCollection 2023 Aug.
Hyaluronic acid (HA) is a crucial component of the extracellular matrix, and its level of accumulation is related to the progression of various malignant tumors. In this study, a pan-cancer analysis of the three enzymes called hyaluronan synthases (HAS1, HAS2, and HAS3) that produce HA was performed. The study comprehensively describes the characteristics of HAS1, HAS2, and HAS3 in cancers using public databases and tools, to identify the potential biological pathways involved at the molecular, protein, cellular, and clinical sample levels. The analysis showed that dysregulation of the three genes often occurs in cancer, contributing to cancer progression, metastasis, and prognosis. Overexpression of HAS2 promotes secretion of HA in GBM and enhances cell proliferation and migration. The common and specific functions of HAS in certain diseases have important research implications for the treatment and prognosis of tumors.
透明质酸（HA）是细胞外基质的关键成分，其积累水平与多种恶性肿瘤的进展相关。在本研究中，对三种产生HA的酶，即透明质酸合酶（HAS1、HAS2和HAS3）进行了泛癌分析。该研究利用公共数据库和工具全面描述了HAS1、HAS2和HAS3在癌症中的特征，以确定在分子、蛋白质、细胞和临床样本水平上涉及的潜在生物学途径。分析表明，这三个基因的失调在癌症中经常发生，促进癌症进展、转移和预后。HAS2的过表达促进GBM中HA的分泌，并增强细胞增殖和迁移。HAS在某些疾病中的共同和特定功能对肿瘤的治疗和预后具有重要的研究意义。
