Yoshinaga Koki, Hashimoto Tomoko, Fukuoka Yuriko, Okuyama Noriyuki, Kyono Koichi
Kyono ART Clinic Takanawa Tokyo Japan.
Reprod Med Biol. 2023 Nov 10;22(1):e12549. doi: 10.1002/rmb2.12549. eCollection 2023 Jan-Dec.
Increasing numbers of women are opting to undergo non-medical oocyte cryopreservation (NMOC). In this report, we present experience at our clinic and discuss NMOC in Japan.
We followed the progress of 403 women who underwent NMOC at our clinic between 2014 and 2021, totaling 592 reproductive cycles.
In total, 61 women underwent oocyte warming and fertility treatment. Of these, 13 women gave birth to 14 children. The median age at first oocyte cryopreservation was 38.3 years, and the oldest pregnant woman was 42 years. Most clients (60%) were in their late 30s. The median time between first oocyte cryopreservation and warming was 3.0 years. One woman was able to achieve a live birth with four vitrified oocytes.
This is the first report in Japan documenting pregnancies and childbirths resulting from NMOC. Ideally, women hope to achieve natural pregnancy between 20 and 32 years of age. NMOC is an option for individuals who are unable to pursue pregnancy during optimal reproductive years and wish to preserve their fertility for future attempts. NMOC is recommended in cases with few indications, and it is necessary to continue accumulating data on its long-term safety and effectiveness.
越来越多的女性选择进行非医学性卵母细胞冷冻保存（NMOC）。在本报告中，我们介绍了我们诊所的经验并讨论了日本的NMOC情况。
我们追踪了2014年至2021年间在我们诊所接受NMOC的403名女性的情况，共计592个生殖周期。
共有61名女性进行了卵母细胞解冻和生育治疗。其中，13名女性生下了14个孩子。首次卵母细胞冷冻保存时的中位年龄为38.3岁，年龄最大的孕妇为42岁。大多数客户（60%）处于30多岁晚期。首次卵母细胞冷冻保存和解冻之间的中位时间为3.0年。一名女性使用4个玻璃化冷冻的卵母细胞成功实现了活产。
这是日本第一份记录NMOC导致妊娠和分娩的报告。理想情况下，女性希望在20至32岁之间实现自然妊娠。NMOC是那些在最佳生育年龄无法怀孕但希望保留生育能力以便未来尝试的个体的一种选择。在适应症较少的情况下推荐NMOC，并且有必要继续积累其长期安全性和有效性的数据。
