Department of Nursing, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, Sichuan, PR China.
Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China.
Eur J Oncol Nurs. 2023 Dec;67:102465. doi: 10.1016/j.ejon.2023.102465. Epub 2023 Nov 7.
To investigate the symptom clusters of Chinese patients with lung cancer, and explore their impact on quality of life (QoL) and each of its functioning.
A cross-sectional study was conducted between October 2022 and April 2023 among 219 lung cancer patients at a general hospital in Sichuan Province. Data were collected using a general information questionnaire, the MD Anderson Symptom Inventory, and the EORTC QLQ-C30. R within the RStudio platform was used to conduct descriptive statistics, exploratory factor analysis and multiple regression analysis.
Psychoneurological, respiratory, gastrointestinal and fatigue-related symptom clusters were identified, each of which was significantly negatively correlated with overall QoL, global health status/QoL and each functioning. The respiratory (β = -0.60, P = 0.02) and fatigue-related symptom cluster (β = -0.86, P = 0.02) were predictors of global health status/QoL; the fatigue-related symptom cluster predicted physical (β = -1.68, P < 0.01), role (β = -1.63, P < 0.01) and cognitive functioning (β = -1.45, P < 0.01); the psychoneurological symptom cluster was a predictor of patients' emotional functioning (β = -1.26, P < 0.01); and the psychoneurological (β = -0.81, P < 0.01) and gastrointestinal symptom cluster (β = -0.60, P = 0.05) predicted social functioning.
Respiratory and fatigue-related symptom clusters were strong predictors of global health status/QoL; fatigue-related, psychoneurological and gastrointestinal symptom clusters had a negative impact on patients' functioning. Nurse practitioners should pay more attention to monitoring respiratory and fatigue-related symptom clusters to identify high-risk populations in time, and tailored interventions based on symptom clusters are needed to synergistically reduce the symptom burden, thereby improving patients' QoL.
调查中国肺癌患者的症状群，并探讨其对生活质量（QoL）及其各功能的影响。
2022 年 10 月至 2023 年 4 月，在四川省一家综合医院对 219 例肺癌患者进行了横断面研究。使用一般信息问卷、MD 安德森症状量表和 EORTC QLQ-C30 收集数据。R 软件在 RStudio 平台上进行描述性统计、探索性因子分析和多元回归分析。
确定了心理神经、呼吸、胃肠道和疲劳相关的症状群，每个症状群与整体 QoL、总体健康状况/QoL 和每个功能均呈显著负相关。呼吸（β=-0.60，P=0.02）和疲劳相关的症状群（β=-0.86，P=0.02）是总体健康状况/QoL 的预测因子；疲劳相关的症状群预测身体（β=-1.68，P<0.01）、角色（β=-1.63，P<0.01）和认知功能（β=-1.45，P<0.01）；心理神经症状群是患者情绪功能的预测因子（β=-1.26，P<0.01）；心理神经（β=-0.81，P<0.01）和胃肠道症状群（β=-0.60，P=0.05）预测社会功能。
呼吸和疲劳相关的症状群是总体健康状况/QoL 的强预测因子；疲劳相关、心理神经和胃肠道症状群对患者的功能有负面影响。执业护士应更加关注监测呼吸和疲劳相关的症状群，及时识别高危人群，并根据症状群进行针对性干预，协同减轻症状负担，从而提高患者的 QoL。
