School of Nursing, Southern Medical University, No.1023, South Shatai Road, Baiyun District, Guangzhou, 510515, Guangdong, China.
Department of Medical Oncology, Nanfang Hospital, Southern Medical University, No.1838, North Guangzhou Avenue, Baiyun District, Guangzhou, 510515, Guangdong, China.
Qual Life Res. 2024 Dec;33(12):3363-3375. doi: 10.1007/s11136-024-03778-x. Epub 2024 Sep 6.
To identify symptom clusters (SCs) in lung cancer patients undergoing chemotherapy and explore their impact on health-related quality of life (HRQoL).
Patients were invited to complete the Chinese version of the M.D. Anderson Symptom Inventory with the Lung Cancer Module and the Quality of Life Questionnaire-core 30. Network analysis was employed to identify SCs. The associations between SCs and each function of HRQoL were examined using the Pearson correlation matrix. Multiple linear regression was applied to analyze the influencing factors of each function of HRQoL.
A total of 623 lung cancer patients who were receiving chemotherapy were recruited. The global health status of lung cancer patients was 59.71 ± 21.09, and 89.73% of patients developed symptoms. Three SCs (Somato-psychological SC, Respiratory SC, and Gastrointestinal SC) were identified, and Somato-psychological SC and Gastrointestinal SC were identified as influencing factors for HRQoL in lung cancer patients.
Most lung cancer patients who undergo chemotherapy experience a range of symptoms, which can be categorized into three SCs. The Somato-psychological SC and Gastrointestinal SC negatively impacted patients' HRQoL. Health care providers should prioritize monitoring these SCs to identify high-risk patients early and implement targeted preventive and intervention measures for each SC, aiming to alleviate symptom burden and enhance HRQoL.
识别正在接受化疗的肺癌患者的症状群（SCs），并探讨其对健康相关生活质量（HRQoL）的影响。
邀请患者完成中文版 M.D.安德森症状评估量表肺癌模块和生活质量问卷核心 30 版。采用网络分析识别SCs。使用 Pearson 相关矩阵分析 SCs 与 HRQoL 各项功能之间的关联。采用多元线性回归分析 HRQoL 各项功能的影响因素。
共纳入 623 例正在接受化疗的肺癌患者。肺癌患者的总体健康状况为 59.71±21.09，89.73%的患者出现症状。确定了三个 SCs（躯体心理 SC、呼吸 SC 和胃肠 SC），躯体心理 SC 和胃肠 SC 被确定为影响肺癌患者 HRQoL 的因素。
大多数接受化疗的肺癌患者经历一系列症状，可以分为三个 SCs。躯体心理 SC 和胃肠 SC 对患者的 HRQoL 产生负面影响。医疗保健提供者应优先监测这些 SCs，以便及早识别高危患者，并针对每个 SC 实施有针对性的预防和干预措施，以减轻症状负担并提高 HRQoL。
