探讨 NO 在脑和脊髓损伤中神经组织中的作用。
Investigation of NO Role in Neural Tissue in Brain and Spinal Cord Injury.
机构信息
Zavoisky Physical-Technical Institute of the Russian Academy of Sciences, 420000 Kazan, Russia.
Department of Human and Animals, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420000 Kazan, Russia.
出版信息
Molecules. 2023 Oct 31;28(21):7359. doi: 10.3390/molecules28217359.
Nitric oxide (NO) production in injured and intact brain regions was compared by EPR spectroscopy in a model of brain and spinal cord injury in Wistar rats. The precentral gyrus of the brain was injured, followed by the spinal cord at the level of the first lumbar vertebra. Seven days after brain injury, a reduction in NO content of 84% in injured brain regions and 66% in intact brain regions was found. The difference in NO production in injured and uninjured brain regions persisted 7 days after injury. The copper content in the brain remained unchanged one week after modeling of brain and spinal cord injury. The data obtained in the experiments help to explain the problems in the therapy of patients with combined brain injury.
采用电子顺磁共振波谱法比较了脑和脊髓损伤模型中损伤和未损伤脑区的一氧化氮（NO）生成。在 Wistar 大鼠中，脑的中央前回受伤，随后在第一腰椎水平的脊髓受伤。脑损伤后 7 天，发现损伤脑区的 NO 含量减少了 84%，未损伤脑区的 NO 含量减少了 66%。损伤和未损伤脑区的 NO 生成差异在损伤后 7 天持续存在。脑损伤和脊髓损伤模型建立一周后，脑内铜含量保持不变。实验中获得的数据有助于解释合并脑损伤患者治疗中的问题。
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