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分析脑-脊髓联合损伤模型建立后脊髓不同节段一氧化氮产生的强度。

Analysis of the Intensity of Nitric Oxide Production in Different Parts of the Spinal Cord after Modeling Combined Cerebral and Spinal Injury.

机构信息

Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, Kazan, Republic of Tatarstan, Russia.

Zavoisky Physical-Technical Institute, Federal Research Center Kazan Scientific Center, Russian Academy of Sciences, Kazan, Republic of Tatarstan, Russia.

出版信息

Bull Exp Biol Med. 2024 Jul;177(3):293-296. doi: 10.1007/s10517-024-06176-y. Epub 2024 Aug 10.

DOI:10.1007/s10517-024-06176-y
PMID:39126540
Abstract

Using the method of electron paramagnetic resonance spectroscopy, we showed that NO production decreases by 60% (p<0.05) in the region located rostral to the spinal cord injury 7 days after combined injury to the brain and spinal cord. At the same time, NO production did not change in the site of spinal cord injury and caudal to the injury. The intensity of NO production in similar parts of the spinal cord in intact animals remained unchanged.

摘要

采用电子顺磁共振波谱法，我们发现，在脑脊髓联合损伤后 7 天，位于脊髓损伤区域的前向区域的 NO 生成减少了 60%（p<0.05）。同时，在脊髓损伤部位和损伤后的尾部，NO 的生成没有变化。在完整动物的脊髓类似部位，NO 生成的强度保持不变。

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本文引用的文献

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Cell. 2022 Aug 4;185(16):2853-2878. doi: 10.1016/j.cell.2022.06.010.
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Roles of Nitric Oxide in Brain Ischemia and Reperfusion.一氧化氮在脑缺血和再灌注中的作用。
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Nitric Oxide-Dependent Pathways as Critical Factors in the Consequences and Recovery after Brain Ischemic Hypoxia.一氧化氮依赖的途径作为脑缺血缺氧后果和恢复的关键因素。
Biomolecules. 2021 Jul 26;11(8):1097. doi: 10.3390/biom11081097.
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Electron paramagnetic resonance spectroscopy reveals alterations in the redox state of endogenous copper and iron complexes in photodynamic stress-induced ischemic mouse liver.电子顺磁共振波谱显示，在光动力应激诱导的缺血性小鼠肝中，内源性铜和铁配合物的氧化还原状态发生改变。
Redox Biol. 2020 Jul;34:101566. doi: 10.1016/j.redox.2020.101566. Epub 2020 May 12.
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Intermittent Hypoxic Conditioning Alleviates Post-Traumatic Stress Disorder-Induced Damage and Dysfunction of Rat Visceral Organs and Brain.间歇性低氧预处理可减轻创伤后应激障碍引起的大鼠内脏器官和脑损伤及功能障碍。
Int J Mol Sci. 2020 Jan 5;21(1):345. doi: 10.3390/ijms21010345.
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The Role of Gaseous Molecules in Traumatic Brain Injury: An Updated Review.气态分子在创伤性脑损伤中的作用：最新综述
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