Sugiyama S, Hayakawa M, Nagai S, Ajioka M, Ozawa T
Life Sci. 1987 Jan 19;40(3):225-31. doi: 10.1016/0024-3205(87)90336-5.
An epoxy derivative of linoleate, 9, 10-epoxy-12-octadecenoate, was demonstrated to be biosynthesized by leukocytes, thus nominated as leukotoxin. Its chemical structure was determined by gas-chromatography/mass spectrometry and nuclear magnetic resonance measurements. When it was injected intravenously, 15 mg/kg, canine heart showed signs of a typical cardiac failure; viz. Aortic flow started to drop immediately after the injection, and fell to 22% of the original at 40 min after the injection. At that point, systolic aortic pressure dropped to 35%, diastolic aortic pressure to 23%, and electronically differentiated maximal rate of left ventricular pressure rise (LV dp/dt) to 29%. All of experimental dogs died 40 to 50 min after the injection. On the contrary, administration of linoleic acid (15 mg/kg) did not affect these hemodynamical parameters. Therefore, leukotoxin seems to be an important factor to the genesis of heart failure.
一种亚油酸的环氧衍生物，9,10 - 环氧 - 12 - 十八碳烯酸，已被证明可由白细胞生物合成，因此被命名为白细胞毒素。其化学结构通过气相色谱/质谱和核磁共振测量确定。当以15毫克/千克的剂量静脉注射时，犬心脏出现典型心力衰竭的迹象；即注射后主动脉血流量立即开始下降，注射后40分钟降至原来的22%。此时，主动脉收缩压降至35%，舒张压降至23%，左心室压力上升的电子微分最大速率（LV dp/dt）降至29%。所有实验犬在注射后40至50分钟死亡。相反，给予亚油酸（15毫克/千克）并未影响这些血液动力学参数。因此，白细胞毒素似乎是心力衰竭发生的一个重要因素。
