Li Mengqi, He Min, Sun Mengmeng, Li Yongping, Li Mengyuan, Jiang Xiaobo, Wang Yanxin, Wang Hongfeng
College of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun, Jilin, China.
Northeast Asia Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, China.
Front Pharmacol. 2024 Dec 19;15:1454348. doi: 10.3389/fphar.2024.1454348. eCollection 2024.
Globally, cardiovascular diseases (CVDs) remain the leading cause of death, and their prevention and treatment continue to face major challenges. Oxylipins, as novel circulating markers of cardiovascular disease, are crucial mediators linking cardiovascular risk factors such as inflammation and platelet activation, and they play an important role in unraveling cardiovascular pathogenesis and therapeutic mechanisms. Chinese herbal medicine plays an important role in the adjuvant treatment of cardiovascular diseases, which has predominantly focused on the key pathways of classic lipids, inflammation, and oxidative stress to elucidate the therapeutic mechanisms of cardiovascular diseases. However,The regulatory effect of traditional Chinese medicine on oxylipins in cardiovascular diseases remains largely unknown. With the increasing number of recent reports on the regulation of oxylipins by Chinese herbal medicine in cardiovascular diseases, it is necessary to comprehensively elucidate the regulatory role of Chinese herbal medicine in cardiovascular diseases from the perspective of oxylipins. This approach not only benefits further research on the therapeutic targets of Chinese herbal medicine, but also brings new perspectives to the treatment of cardiovascular diseases.
在全球范围内，心血管疾病（CVDs）仍然是主要的死亡原因，其预防和治疗继续面临重大挑战。氧化脂质作为心血管疾病的新型循环标志物，是连接炎症和血小板活化等心血管危险因素的关键介质，在揭示心血管发病机制和治疗机制方面发挥着重要作用。中药在心血管疾病的辅助治疗中发挥着重要作用，主要集中在经典脂质、炎症和氧化应激的关键途径上，以阐明心血管疾病的治疗机制。然而，中药对心血管疾病中氧化脂质的调节作用在很大程度上仍然未知。随着最近关于中药在心血管疾病中对氧化脂质调节作用的报道越来越多，有必要从氧化脂质的角度全面阐明中药在心血管疾病中的调节作用。这种方法不仅有利于进一步研究中药的治疗靶点，也为心血管疾病的治疗带来了新的视角。
