Rao T K, Ramey D W, Lijinsky W, Epler J L
Mutat Res. 1979 May;67(1):21-6. doi: 10.1016/0165-1218(79)90095-8.
Mutagenicity of cyclic nitrosamines with varying carcinogenic potentials was assayed in the Salmonella histidine-reversion system. Mutagenicity in the pour-plate assay was compared with that in the liquid pre-incubation test. The smaller ring compounds (nitrosoazetidine, nitrosopyrrolidine, and nitrosopiperidine) exhibited a similar effect in both assays. The large ring compounds (nitrosohexamethyleneimine, nitrosoheptamethyleneimine, nitrosooctamethyleneimine, and nitrosododecamethyleneimine) were more effective in the liquid pre-incubation test. Our results suggest a reasonable relationship between their mutagenic and carcinogenic activities.
在鼠伤寒沙门氏菌组氨酸回复突变系统中检测了具有不同致癌潜力的环状亚硝胺的诱变性。将倾注平板试验中的诱变性与液体预孵育试验中的诱变性进行了比较。较小环的化合物（亚硝基氮杂环丁烷、亚硝基吡咯烷和亚硝基哌啶）在两种试验中表现出相似的效果。大环化合物（亚硝基六亚甲基亚胺、亚硝基七亚甲基亚胺、亚硝基八亚甲基亚胺和亚硝基十二亚甲基亚胺）在液体预孵育试验中更有效。我们的结果表明了它们的诱变活性和致癌活性之间的合理关系。
