Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Presently at Baylor-Scott & White Hospital System, Dallas, TX, USA.
J Perinatol. 2024 Jan;44(1):78-86. doi: 10.1038/s41372-023-01821-2. Epub 2023 Nov 14.
The primary objectives were to compare body mass index (BMI) Z-score (Z), systolic blood pressure (SBP), serum leptin:adiponectin (L:A) ratio and estimated glomerular filtration rate (eGFR) at ~3 years adjusted age between two arms of a randomized controlled trial (RCT) comparing two modes of human milk fortification for very low-birthweight infants in the neonatal intensive care unit.
Follow-up of RCT at 33-48 months.
Follow-up data are available in 82/120 infants. Infants in the experimental arm have anthropometric data consistent with central obesity and higher serum L:A ratio (sensitivity analysis adjusting for sex and using all available data), but have similar eGFR and SBP at follow-up compared with controls. Serum L:A ratio is strongly correlated with anthropometric measurements suggesting central obesity.
Infants in the experimental arm have central obesity and higher serum L:A ratio compared with controls. Notably, serum L:A ratio is strongly correlated with weight gain.
This randomized controlled trial was registered at ClinicalTrials.gov NCT02372136.
本研究旨在比较新生儿重症监护病房中极低出生体重儿两种母乳强化方式随机对照试验（RCT）两个组别的体重指数（BMI）Z 评分（Z）、收缩压（SBP）、血清瘦素：脂联素（L：A）比值和估算肾小球滤过率（eGFR）在调整年龄约 3 年后的差异。
RCT 的随访研究。
82/120 例婴儿可获得随访数据。实验组婴儿的人体测量数据与中心性肥胖一致，且血清 L：A 比值较高（性别调整后的敏感性分析和使用所有可用数据），但与对照组相比，随访时的 eGFR 和 SBP 相似。血清 L：A 比值与人体测量指标密切相关，提示存在中心性肥胖。
实验组婴儿与对照组相比存在中心性肥胖和较高的血清 L：A 比值。值得注意的是，血清 L：A 比值与体重增加密切相关。
本随机对照试验已在 ClinicalTrials.gov 注册，编号为 NCT02372136。
