Department of Ophthalmology, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanishiku, Kitakyushu, 807-8555, Japan.
Department of Environmental Epidemiology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Jpn J Ophthalmol. 2024 Jan;68(1):19-25. doi: 10.1007/s10384-023-01031-5. Epub 2023 Nov 15.
To develop a method to measure the macular pigment optical density (MPOD) using scanning laser ophthalmoscopic images in young adults and children.
Cross-sectional study.
Blue light reflectance fundus images of 32 healthy subjects were used. A profile of the linear reflectance changes across the center of the fovea on a grayscale fundus image was generated. The ratio of the macula-to-periphery reflection was designated as the peak value of the MPOD (MPOD) based on established fundamentals. In the MPOD profile, the basal width of the pixels at MPOD < 0 (wMP) and width at one-half value of the MPOD (wMP) were determined. The MOPD at eccentricity of 0.5° was measured by heterochromatic flicker photometry (MPOD), and the correlation between the MPOD and MPOD was evaluated.
The MPOD ranged from 0.17 to 0.73 with a mean of 0.40 ± 0.13. The wMP ranged from 88 to 173 pixels with a mean of 121.7 ± 24.2 pixels, and the wMP ranged from 38 to 83 pixels with a mean of 54.1 ± 10.3 pixels. A significant correlation was found between the MPOD and MPOD (r = 0.41, P = 0.02).
This simplified method can provide accurate and reliable values of the MPOD comparable to heterochromatic flicker photometry. Obtaining the fundus images in this fast and easy way should be suitable for children thus enabling clinicians to determine the MPODs for children.
开发一种使用扫描激光眼科图像在年轻成年人和儿童中测量黄斑色素光学密度（MPOD）的方法。
横断面研究。
使用 32 名健康受试者的蓝光反射眼底图像。在灰度眼底图像上生成穿过中央凹的线性反射变化的轮廓。根据既定原理，将黄斑与周围反射的比率指定为 MPOD（MPOD）的峰值。在 MPOD 分布中，确定 MPOD<0 处的像素基底宽度（wMP）和 MPOD 处的一半值的宽度（wMP）。通过对比闪光视敏度（MPOD）测量 0.5°偏心处的 MOPD，并评估 MPOD 与 MPOD 的相关性。
MPOD 范围为 0.17 至 0.73，平均值为 0.40±0.13。wMP 范围为 88 至 173 像素，平均值为 121.7±24.2 像素，wMP 范围为 38 至 83 像素，平均值为 54.1±10.3 像素。MPOD 与 MPOD 之间存在显著相关性（r=0.41，P=0.02）。
这种简化的方法可以提供与对比闪光视敏度相当的准确可靠的 MPOD 值。以这种快速简便的方式获取眼底图像应该适合儿童，从而使临床医生能够确定儿童的 MPOD。
