Chauveau P, Lebkiri B, Ployard F, Ciancioni C, Man N K, Jungers P
Nephrologie. 1986;7(4):137-42.
We prospectively compared the efficacy and tolerance of a very low protein intake (0.4 g/kg/day) supplemented with keto analogues of essential amino acids and of the standard low protein diet (0.6 g/kg/day) in 19 patients with advanced chronic renal failure (mean plasma creatinine level: 726 +/- 113 mumol/l), who were randomly assigned to either treatment. Long term acceptability was similarly good in both groups and no biochemical or morphometric sign of denutrition was observed in neither group, whereas the mean renal survival duration until dialysis was longer, and the mean slope of 1/Cr was lower in patients treated with keto analogues. We suggest that ketoacid treatment is more effective than protein restriction alone in slowing the progression of advanced chronic renal failure.
我们前瞻性地比较了19例晚期慢性肾衰竭患者（平均血浆肌酐水平：726±113μmol/L）中，补充必需氨基酸酮类似物的极低蛋白摄入量（0.4g/kg/天）与标准低蛋白饮食（0.6g/kg/天）的疗效和耐受性，这些患者被随机分配至两种治疗方案。两组的长期可接受性同样良好，且两组均未观察到营养不良的生化或形态学迹象，然而，接受酮类似物治疗的患者直至透析的平均肾脏存活时间更长，且1/Cr的平均斜率更低。我们认为，在延缓晚期慢性肾衰竭进展方面，酮酸治疗比单纯蛋白质限制更有效。
