• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

种植体周围黏膜中的炎症基因谱与颗粒存在情况：一项针对9例患者的初步研究

Inflammatory Gene Profile and Particle Presence in Peri-Implant Mucosa: a Pilot Study on 9 Patients.

作者信息

Olander Julia, Barkarmo Sargon, Hammarström Johansson Petra, Wennerberg Ann, Stenport Victoria Franke

机构信息

Department of Prosthodontics and Dental Materials Science, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, GothenburgSweden.

出版信息

J Oral Maxillofac Res. 2023 Sep 30;14(3):e2. doi: 10.5037/jomr.2023.14302. eCollection 2023 Jul-Sep.

DOI:10.5037/jomr.2023.14302
PMID:37969950
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10645473/
Abstract

OBJECTIVES

The purpose of this pilot study is to compare gene expression in mucosa around dental implants with zirconia abutment to titanium and investigate presence of particles in mucosa samples and on implant heads.

MATERIAL AND METHODS

Ten patients with a single implant supported prosthesis connected to zirconia or titanium abutments were invited at the five-year control. A clinical examination and a survey on experience of function and appearance were conducted. A mucosa biopsy taken in close vicinity to the implant were analysed by real-time polymerase chain reaction (qPCR) and presence of particles in a scanning electron microscope/energy-dispersive X-ray spectroscope (SEM/EDX). Cytological smear samples were collected and analysed through inductively coupled plasma mass spectrometry (ICP-MS) to investigate presence of particles on implant heads.

RESULTS

In total, 9 patients participated in the study, five with titanium abutments and four with zirconia abutments. All patients were satisfied with function and aesthetics. Titanium and iron particles were detected in mucosa biopsies. The ICP - MS analysis demonstrated presence of zirconia and titanium. Several proinflammatory genes were upregulated in the zirconia abutment group.

CONCLUSIONS

Around zirconia abutments a slight increase in proinflammatory response and amount of wear particles was seen as compared to titanium. Wear particles of titanium were present in all soft tissue samples, however zirconia particles only in the samples from implants heads/mucosa with zirconia abutments.

摘要

目的

本初步研究的目的是比较使用氧化锆基台的牙种植体周围黏膜与钛基台周围黏膜的基因表达，并调查黏膜样本和种植体头部颗粒的存在情况。

材料与方法

邀请10名使用连接氧化锆或钛基台的单颗种植体支持修复体的患者进行五年期复查。进行了临床检查以及关于功能和外观体验的调查。通过实时聚合酶链反应（qPCR）分析在种植体附近采集的黏膜活检样本，并使用扫描电子显微镜/能量色散X射线光谱仪（SEM/EDX）检测颗粒的存在情况。收集细胞学涂片样本并通过电感耦合等离子体质谱法（ICP-MS）进行分析，以调查种植体头部颗粒的存在情况。

结果

共有9名患者参与了研究，其中5名使用钛基台，4名使用氧化锆基台。所有患者对功能和美观都很满意。在黏膜活检样本中检测到了钛和铁颗粒。ICP-MS分析表明存在氧化锆和钛。氧化锆基台组中几种促炎基因上调。

结论

与钛基台相比，氧化锆基台周围的促炎反应和磨损颗粒量略有增加。所有软组织样本中均存在钛磨损颗粒，然而氧化锆颗粒仅存在于来自使用氧化锆基台的种植体头部/黏膜的样本中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fb1/10645473/b095e045d85e/jomr-14-e2-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fb1/10645473/946d7875cba7/jomr-14-e2-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fb1/10645473/7087004ade09/jomr-14-e2-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fb1/10645473/0c521ae7129e/jomr-14-e2-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fb1/10645473/9aec41476096/jomr-14-e2-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fb1/10645473/bda7a45f1bd9/jomr-14-e2-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fb1/10645473/14a80e224428/jomr-14-e2-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fb1/10645473/b095e045d85e/jomr-14-e2-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fb1/10645473/946d7875cba7/jomr-14-e2-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fb1/10645473/7087004ade09/jomr-14-e2-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fb1/10645473/0c521ae7129e/jomr-14-e2-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fb1/10645473/9aec41476096/jomr-14-e2-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fb1/10645473/bda7a45f1bd9/jomr-14-e2-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fb1/10645473/14a80e224428/jomr-14-e2-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fb1/10645473/b095e045d85e/jomr-14-e2-g007.jpg

相似文献

1
Inflammatory Gene Profile and Particle Presence in Peri-Implant Mucosa: a Pilot Study on 9 Patients.种植体周围黏膜中的炎症基因谱与颗粒存在情况：一项针对9例患者的初步研究
J Oral Maxillofac Res. 2023 Sep 30;14(3):e2. doi: 10.5037/jomr.2023.14302. eCollection 2023 Jul-Sep.
2
Wear at the titanium-titanium and the titanium-zirconia implant-abutment interface: a comparative in vitro study.钛-钛及钛-氧化锆种植体-基台界面的磨损：一项体外比较研究。
Dent Mater. 2012 Dec;28(12):1215-20. doi: 10.1016/j.dental.2012.08.008. Epub 2012 Sep 27.
3
Wear at the titanium-zirconia implant-abutment interface: a pilot study.钛-氧化锆种植体-基台界面的磨损：一项初步研究。
Int J Oral Maxillofac Implants. 2011 Sep-Oct;26(5):970-5.
4
An Esthetic Evaluation of Different Abutment Materials in the Anterior Maxilla: A Randomized Controlled Clinical Trial Using a Crossover Design.上颌前部不同基台材料的美学评价：一项采用交叉设计的随机对照临床试验。
J Prosthodont. 2022 Oct;31(8):673-680. doi: 10.1111/jopr.13520. Epub 2022 May 16.
5
Peri-implant soft tissue colour around titanium and zirconia abutments: a prospective randomized controlled clinical study.钛基台和氧化锆基台周围种植体周围软组织颜色：一项前瞻性随机对照临床研究。
Clin Oral Implants Res. 2015 May;26(5):537-44. doi: 10.1111/clr.12440. Epub 2014 Jun 24.
6
Abutment Material Effect on Peri-implant Soft Tissue Color and Perceived Esthetics.基台材料对种植体周围软组织颜色及美学效果的影响。
J Prosthodont. 2016 Dec;25(8):634-640. doi: 10.1111/jopr.12360. Epub 2015 Sep 23.
7
Cement thickness at implant-supported single-tooth Lava assemblies: a scanning electron microscopic investigation.种植体支持的单颗 Lava 修复体的粘结剂厚度：扫描电子显微镜研究。
Clin Oral Implants Res. 2010 Jul;21(7):747-50. doi: 10.1111/j.1600-0501.2009.01882.x.
8
Quantitative discoloration assessment of peri-implant soft tissue around zirconia and other abutments with different colours: A systematic review and meta-analysis.定量评估不同颜色氧化锆基台及其他基台周围种植体周围软组织变色：系统评价和荟萃分析。
J Dent. 2018 Mar;70:110-117. doi: 10.1016/j.jdent.2018.01.003. Epub 2018 Jan 19.
9
Impact of abutment material on peri-implant soft tissue color. An in vitro study.基台材料对种植体周围软组织颜色的影响。一项体外研究。
Clin Oral Investig. 2017 Sep;21(7):2221-2233. doi: 10.1007/s00784-016-2015-9. Epub 2016 Nov 22.
10
Spectrophotometric assessment of peri-implant mucosa after restoration with zirconia abutments veneered with fluorescent ceramic: a controlled, retrospective clinical study.用荧光陶瓷贴面氧化锆基台修复后种植体周围黏膜的分光光度评估：一项对照性回顾性临床研究。
Clin Oral Implants Res. 2013 Aug;24 Suppl A100:28-33. doi: 10.1111/j.1600-0501.2011.02361.x. Epub 2011 Dec 6.

引用本文的文献

1
Peri-Implant Oral Squamous Cell Carcinoma (OSCC): Clinicopathological Features and Staging Issues.种植体周围口腔鳞状细胞癌（OSCC）：临床病理特征与分期问题
Cancers (Basel). 2025 Jun 26;17(13):2149. doi: 10.3390/cancers17132149.

本文引用的文献

1
Implant-Supported Single Crowns with Titanium or Zirconia Abutments: A Retrospective Up-to-5-year Follow-up Study.种植体支持的单冠修复体，采用钛或氧化锆基台：一项长达 5 年的回顾性随访研究。
Int J Prosthodont. 2022 Jul-Aug;35(4):387-395. doi: 10.11607/ijp.7342.
2
The role of foreign body response in peri-implantitis: What is the evidence?异物反应在种植体周围炎中的作用：有何证据？
Periodontol 2000. 2022 Oct;90(1):176-185. doi: 10.1111/prd.12456. Epub 2022 Aug 2.
3
Bone remodeling: an operational process ensuring survival and bone mechanical competence.
骨重塑：一个确保骨骼存活和力学性能的运作过程。
Bone Res. 2022 Jul 18;10(1):48. doi: 10.1038/s41413-022-00219-8.
4
Mechanical behavior of titanium and zirconia abutments at the implant-abutment interface: A systematic review.钛和氧化锆基台在种植体-基台界面的力学行为：系统评价。
J Prosthet Dent. 2024 Mar;131(3):420-426. doi: 10.1016/j.prosdent.2022.01.006. Epub 2022 Mar 12.
5
Wear particle release at the interface of dental implant components: Effects of different material combinations. An in vitro study.种植体组件界面的磨屑释放：不同材料组合的影响。一项体外研究。
Dent Mater. 2022 Mar;38(3):508-516. doi: 10.1016/j.dental.2022.01.001. Epub 2022 Jan 19.
6
Titanium Nitride Coated Implant Abutments: From Technical Aspects And Soft tissue Biocompatibility to Clinical Applications. A Literature Review.氮化钛涂层种植体基台：从技术方面和软组织生物相容性到临床应用。文献综述。
J Prosthodont. 2022 Aug;31(7):571-578. doi: 10.1111/jopr.13446. Epub 2021 Nov 20.
7
Effect of Fabrication Technique on the Microgap of CAD/CAM Cobalt-Chrome and Zirconia Abutments on a Conical Connection Implant: An In Vitro Study.制作技术对锥形连接种植体上CAD/CAM钴铬合金和氧化锆基台微间隙的影响：一项体外研究。
Materials (Basel). 2021 Apr 30;14(9):2348. doi: 10.3390/ma14092348.
8
The good, the bad and the ugly: G-CSF, ageing and neutrophils-Implications for severe COVID-19.好的、坏的和丑的：G-CSF、衰老和中性粒细胞——对严重 COVID-19 的影响。
J Leukoc Biol. 2021 Jun;109(6):1017-1018. doi: 10.1002/JLB.3CE0121-002R. Epub 2021 Apr 18.
9
Titanium particles: An emerging risk factor for peri-implant bone loss.钛颗粒：种植体周围骨丢失的一个新出现的风险因素。
Saudi Dent J. 2020 Sep;32(6):283-292. doi: 10.1016/j.sdentj.2019.09.008. Epub 2019 Oct 8.
10
Inhibition of neutrophil elastase prevents neutrophil extracellular trap formation and rescues mice from endotoxic shock.抑制中性粒细胞弹性蛋白酶可防止中性粒细胞胞外诱捕网的形成，并挽救内毒素性休克小鼠的生命。
Biomaterials. 2020 Apr;238:119836. doi: 10.1016/j.biomaterials.2020.119836. Epub 2020 Feb 3.