Sachelariu N, Soranzo M L, Bosio G, Sattinger M, Bramato C, Salassa B
Minerva Med. 1979 Jul 14;70(32):2255-64.
Following a review of the latest methods of treating infections of the urinary ways, the pharmacokinetic and clinical results of a new antibiotic, Carfecillin, are reported. The examination was carried out on a total of 10 volunteers. The substance showed good serum levels and fair renal excretion with both the 250 mg and the 500 mg p.o. doses. The clinical study was carried out on a double blind basis versus a standard reference (indanyl ester of carbenicillin) in 26 patients and showed the electivity of the antibiotic in the oral treatment of urinary infections under well tolerated conditions.
在回顾了治疗尿路感染的最新方法后，报告了一种新型抗生素羧苄青霉素苯酯的药代动力学和临床结果。该试验共对10名志愿者进行。250毫克和500毫克口服剂量的药物均显示出良好的血清水平和适度的肾脏排泄。临床研究以双盲方式对26名患者与标准对照物（羧苄青霉素茚满酯）进行比较，结果表明该抗生素在耐受性良好的情况下对尿路感染的口服治疗具有选择性。
