Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Vaccines Research and Review, Division of Bacterial Parasitic and Allergenic Products, Laboratory of Mucosal Pathogens and Cellular Immunology, Silver Spring, Maryland, USA.
J Bacteriol. 2023 Dec 19;205(12):e0032423. doi: 10.1128/jb.00324-23. Epub 2023 Nov 16.
This study is the first example of growing with siderophores as the sole iron source and describes the characterization of the ferric hydroxamate uptake ABC transporter (FhuDBGC). This transporter shows specificity to the siderophore ferrichrome. While not required for pathogenesis, this transporter highlights the redundancy in iron acquisition mechanisms that uses to compete for iron during an infection.
这项研究是首例以铁载体作为唯一铁源进行生长的例子，并描述了三价羟肟酸盐摄取 ABC 转运体（FhuDBGC）的特性。该转运体对铁载体ferrichrome 具有特异性。虽然它不是致病所必需的，但该转运体突出了铁获取机制的冗余性，这些机制在感染期间用于争夺铁。
