南非临床分离株的 manogepix 药敏试验。
manogepix susceptibility testing of South African , and clinical isolates.
机构信息
National Institute for Communicable Diseases (NICD), a Division of the National Health Laboratory Service, Johannesburg, South Africa.
School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Witwatersrand, South Africa.
出版信息
Antimicrob Agents Chemother. 2023 Dec 14;67(12):e0110423. doi: 10.1128/aac.01104-23. Epub 2023 Nov 16.
Abstract
We performed antifungal susceptibility testing of manogepix against the yeast phase of 78 , 2 and 5 isolates using a reference broth microdilution method following Clinical and Laboratory Standards Institute recommendations. All three pathogens had low minimum inhibitory concentrations ranging from <0.0005 to 0.008 mg/L. Manogepix should be investigated in animal models and potentially in future human clinical trials for endemic mycoses.
摘要
我们使用参考肉汤微量稀释法，按照临床和实验室标准协会的建议，对 78、2 和 5 株念珠菌的酵母相进行了曼戈匹克斯的抗真菌药敏试验。所有三种病原体的最低抑菌浓度都很低，范围在<0.0005 至 0.008mg/L 之间。曼戈匹克斯应该在动物模型中进行研究，并有可能在未来的人类临床试验中用于地方性真菌感染。
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