Zhang Tong, Liu Wenxu, Lu Huimin, Cheng Ting, Wang Linlin, Wang Gang, Zhang Hao, Chen Wei
State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, China.
School of Food Science and Technology, Jiangnan University, Wuxi, China.
Crit Rev Food Sci Nutr. 2025;65(3):551-574. doi: 10.1080/10408398.2023.2278155. Epub 2023 Nov 16.
Constipation is a prevalent gastrointestinal symptom that can considerably affect a patients' quality of life. Although several drugs have been used to treat constipation, they are associated with high costs, side effects, and low universality. Therefore, alternative intervention strategies are urgently needed. Traditional lactic acid bacteria (LAB), such as and , play a vital role in regulating intestinal microecology and have demonstrated favorable effects in constipation; however, a comprehensive review of their constipation relief mechanisms is limited. This review summarizes the pathogenesis of constipation and the relationship between intestinal motility and gut microbiota, elucidates the possible mechanism by which LAB alleviates of constipation through a systematic summary of animal and clinical research, and highlights the challenges and applications of LAB in the treatment of constipation. Our review can improve our understanding of constipation, and advance targeted microecological therapeutic agents, such as LAB.
便秘是一种常见的胃肠道症状，会严重影响患者的生活质量。尽管已有多种药物用于治疗便秘，但它们存在成本高、副作用大以及通用性低的问题。因此，迫切需要替代性干预策略。传统乳酸菌（LAB），如[具体菌种1]和[具体菌种2]，在调节肠道微生态方面发挥着至关重要的作用，并且已在便秘治疗中显示出良好效果；然而，对其缓解便秘机制的全面综述较为有限。本综述总结了便秘的发病机制以及肠道动力与肠道微生物群之间的关系，通过系统总结动物和临床研究阐明了LAB缓解便秘的可能机制，并强调了LAB在便秘治疗中的挑战和应用。我们的综述能够增进我们对便秘的理解，并推动如LAB这类有针对性的微生态治疗药物的发展。
