Department of Pharmaceutics, Pharmacy College, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, PR China; Hunan Key Laboratory of Druggability and Preparation Modification for Traditional Chinese Medicine, Changsha, Hunan 410208, PR China.
Department of Pharmaceutics, Pharmacy College, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, PR China; Hunan Key Laboratory of Druggability and Preparation Modification for Traditional Chinese Medicine, Changsha, Hunan 410208, PR China; Supramolecular Mechanism and Mathematic-Physics Characterization for Chinese Materia Medicine, Changsha, Hunan 410208, PR China.
J Ethnopharmacol. 2024 Mar 25;322:117278. doi: 10.1016/j.jep.2023.117278. Epub 2023 Nov 14.
Lonicerae japonicae flos (LJF) and Lonicerae flos (LF) belong to different genera of Caprifoliaceae with analogous appearances and functions. Historically, they have been used as herbal medicines to treat various diseases with confirmed wind-heat evacuation, heat-clearing, and detoxification effects. However, the Chinese Pharmacopoeia (2005 Edition) lists LJF and LF under different categories.
Few studies have systematically compared the similarities and dissimilarities of LJF and LF concerning their research achievements. This systematic review and comparison of the traditional use, identification, and phytochemical and pharmacological properties of LJF and LF provides valuable insights for their further application and clinical safety.
Related document information was collected from databases that included Web of Science, X-MOL, Science Direct, PubMed, and the China National Knowledge Infrastructure.
The chemical constituents and pharmacological effects of LJF and LF were similar. A total of 337 and 242 chemical constituents were isolated and identified in LJF and LF, respectively. These included volatile oils, cyclic ether terpenes, flavonoids, phenolic acids, triterpenoids, and their saponins. Additionally, LJF plants contain more iridoids and flavonoids than LF plants. The latter have a variety of triterpenoid saponins and significantly higher chlorogenic acid content than LJF plants. Pharmacological studies have shown that LJF and LF have various anti-inflammatory, antiviral, antibacterial, anti-endotoxic, antioxidant, anti-tumor, anti-platelet, myocardial protective, and hepatoprotective effects.
This review was undertaken to explore whether LJF and LF should be listed separately in the Chinese Pharmacopoeia in terms of their disease prevention and treatment strategies. Although LJF and LF showed promising effects, their action mechanisms remains unclear. Specifically, their impact on gut microbiota, gastrointestinal tract, and blood parameters requires further investigation. These studies will provide the foundation for scientific utilization and clinical/non-clinical applications of LJF and LF, and the maximum benefits from their mutual use.
金银花（LJF）和金银花（LF）属于忍冬科不同属，具有相似的外观和功能。历史上，它们被用作草药，用于治疗各种疾病，具有祛风清热、清热解毒的功效。然而，《中国药典》（2005 年版）将 LJF 和 LF 列入不同类别。
很少有研究系统比较 LJF 和 LF 在研究成果方面的异同。本研究系统综述和比较了 LJF 和 LF 的传统用途、鉴定以及植物化学和药理学特性，为它们的进一步应用和临床安全性提供了有价值的见解。
相关文献信息从包括 Web of Science、X-MOL、Science Direct、PubMed 和中国知网在内的数据库中收集。
LJF 和 LF 的化学成分和药理作用相似。LJF 和 LF 中分别分离和鉴定了 337 种和 242 种化学成分。这些包括挥发油、环醚萜类、类黄酮、酚酸、三萜及其皂苷。此外，LJF 植物比 LF 植物含有更多的环烯醚萜苷和类黄酮。后者具有多种三萜皂苷，且绿原酸含量明显高于 LJF 植物。药理研究表明，LJF 和 LF 具有多种抗炎、抗病毒、抗菌、抗内毒素、抗氧化、抗肿瘤、抗血小板、心肌保护和保肝作用。
本综述旨在探讨在疾病防治策略方面，LJF 和 LF 是否应该分别列入《中国药典》。虽然 LJF 和 LF 表现出良好的效果，但它们的作用机制尚不清楚。具体来说，它们对肠道微生物群、胃肠道和血液参数的影响需要进一步研究。这些研究将为 LJF 和 LF 的科学利用和临床/非临床应用提供基础，并从它们的相互应用中获得最大的益处。
