Thakur Sheetal, Azad Ramesh K, Chauhan Ishan, Thakur Jagdeep S
Department of Otolaryngology-Head Neck Surgery (ENT), Indira Gandhi Medical College, Shimla, 171001 India.
Indian J Otolaryngol Head Neck Surg. 2023 Dec;75(4):3130-3135. doi: 10.1007/s12070-023-03936-6. Epub 2023 Jun 13.
Health related quality of life (HRQOL) is a multidimensional concept that encompasses the patient's perceptions of his or her physical, emotional, social, and cognitive functions. Despite DTC patients' long survival, HRQOL has been shown to be lower than in the general population. There is a scarcity of data on HRQOL in thyroid cancer in the Indian population and especially goiter endemic area. As a result, the authors conducted a health-related quality of life survey in patients managed at their center in Northern India's Sub-Himalayan region using two widely accepted questionnaires. Adults with differentiated thyroid cancer who had surgery with or without radio-iodine ablation and had recovered for at least 6 months were assessed using health quality of life surveys, the QLQ-C30 and QLQ-THY34 of the European Organization for Research and Treatment of Cancer Quality of Life Group. The survey was completed by 57 adults with a mean age of 45.64 ± 15.64 years. The average time between the survey and treatment was 13.3 ± 10.8 months. After surgery, the QLQ-C30 found a significant reduction in insomnia, appetite loss, constipation, diarrhea, and financial difficulties, whereas radio-iodine ablation significantly improved global health status. The QLQ-THY34 found a significant increase in symptoms such as voice concerns, hair problems, dry mouth, shoulder functioning, tingling, and worrying after surgery, with a significant improvement in swallowing and job impact symptoms. The surgical extent had no impact. The quality of life for people with differentiated thyroid cancer in goiter-endemic areas is similar to that of other areas. However, the limited number of subjects in the study warrants further large sample size longitudinal study to understand the exact Health-related quality of life in thyroid cancer in endemic area.
健康相关生活质量（HRQOL）是一个多维度概念，涵盖患者对其身体、情感、社会和认知功能的感知。尽管分化型甲状腺癌（DTC）患者生存期长，但研究表明其健康相关生活质量低于普通人群。关于印度人群尤其是甲状腺肿流行地区甲状腺癌患者健康相关生活质量的数据稀缺。因此，作者使用两份广泛认可的问卷，对印度北部喜马拉雅地区中心治疗的患者进行了健康相关生活质量调查。使用欧洲癌症研究与治疗组织生活质量小组的QLQ-C30和QLQ-THY34生活质量调查问卷，对接受手术（无论有无放射性碘消融）且已康复至少6个月的成年分化型甲状腺癌患者进行评估。57名平均年龄为45.64±15.64岁的成年人完成了调查。调查与治疗之间的平均时间为13.3±10.8个月。手术后，QLQ-C30发现失眠、食欲减退、便秘、腹泻和经济困难显著减少，而放射性碘消融显著改善了总体健康状况。QLQ-THY34发现手术后声音问题、头发问题、口干、肩部功能、刺痛和担忧等症状显著增加，吞咽和工作影响症状显著改善。手术范围没有影响。甲状腺肿流行地区分化型甲状腺癌患者的生活质量与其他地区相似。然而，该研究中受试者数量有限，需要进一步开展大样本纵向研究，以了解流行地区甲状腺癌患者确切的健康相关生活质量。
