Kirkpatrick J B, Hayman L A
Radiology. 1987 Feb;162(2):509-11. doi: 10.1148/radiology.162.2.3797666.
Patchy white-matter lesions occur in the magnetic resonance (MR) imaging brain studies of 20%-30% of neurologically healthy elderly subjects. To determine the frequency of histologically verifiable white-matter lesions at autopsy in such subjects the authors examined serial, microscopic, whole brain sections from 15 clinically healthy subjects aged 52-72 years. Small white-matter lesions were found in 12. In these 12, zones of atrophic perivascular demyelination were present in eight brains. These are not the familiar thrombotic, embolic, or ischemic vascular lesions that produce acute necrosis. This mild vascular insufficiency produces atrophy, which has been recognized in the pathology literature but whose clinical significance remains unknown. Other lesions seen were small vascular malformations in the centrum ovale in four brains, diverticula of the lateral ventricle extending into the white matter in three, and an isolated central white-matter infarction in one. All of these lesions are probably the basis of the patchy white-matter lesions seen on MR imaging studies in the neurologically healthy elderly population.
在20%-30%神经系统健康的老年受试者的磁共振成像（MR）脑部研究中，出现了斑片状白质病变。为了确定此类受试者尸检时组织学上可证实的白质病变的发生率，作者检查了15名年龄在52-72岁临床健康受试者的连续、显微镜下全脑切片。在12名受试者中发现了小的白质病变。在这12名受试者中，8例大脑存在萎缩性血管周围脱髓鞘区域。这些病变并非导致急性坏死的常见血栓性、栓塞性或缺血性血管病变。这种轻度血管功能不全导致萎缩，这在病理学文献中已得到认可，但其临床意义仍不清楚。其他可见病变包括4例大脑卵圆中心的小血管畸形、3例侧脑室憩室延伸至白质以及1例孤立的中央白质梗死。所有这些病变可能是神经系统健康老年人群MR成像研究中所见斑片状白质病变的基础。
