Department of Rehabilitation Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Metab Brain Dis. 2024 Feb;39(2):295-311. doi: 10.1007/s11011-023-01324-1. Epub 2023 Nov 18.
This study aims to assess the effects of exercise on cognitive impairment behavioral performance and neuroprotective mechanisms in diabetes mellitus (DM) animal models. PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang Database, VIP Database (VIP), and China Biomedical Literature Database (CBM) were systematically searched for studies investigating the impact of exercise on cognitive impairment in animal models of diabetes mellitus (DM) from the inception of these databases through July 2023. Rigorous quality assessments were conducted on the included literature. Primary outcome measures comprised fasting blood glucose (FBG) levels and performance in the Morris water maze test, while secondary outcomes focused on mechanisms related to neuroprotection. Statistical analysis of outcome data was conducted using RevMan 5.3 and R software. A total of 17 studies were included, encompassing 399 animals. The results of the meta-analysis of primary outcome measures revealed that, compared to the control group, exercise effectively reduced fasting blood glucose (FBG) levels in diabetic animal models. In the Morris water maze experiment, exercise also significantly decreased the escape latency of diabetic animal models, increased the number of platform crossings, improved the percentage of time spent in the target quadrant, extended the time spent in the target quadrant, and enhanced swimming speed. Meta-analysis of secondary outcome measures indicated that exercise effectively reduced Aβ deposition, attenuated oxidative stress, enhanced synaptic function, suppressed cellular apoptosis and neuroinflammation, and promoted neurogenesis. Exercise represents a promising non-pharmacological therapy with a positive impact on diabetes-related cognitive function and neuroprotection. Moreover, this study provides a theoretical foundation for further preclinical and clinical trials.
本研究旨在评估运动对糖尿病（DM）动物模型认知障碍、行为表现和神经保护机制的影响。系统检索了 PubMed、Embase、Web of Science、中国知网（CNKI）、万方数据库、维普数据库（VIP）和中国生物医学文献数据库（CBM），以获取从这些数据库建立到 2023 年 7 月期间研究运动对糖尿病动物模型认知障碍影响的相关文献。对纳入文献进行了严格的质量评估。主要结局指标包括空腹血糖（FBG）水平和 Morris 水迷宫测试中的表现，次要结局指标则关注与神经保护相关的机制。使用 RevMan 5.3 和 R 软件对结局数据进行统计分析。共纳入 17 项研究，包含 399 只动物。主要结局指标的荟萃分析结果表明，与对照组相比，运动可有效降低糖尿病动物模型的空腹血糖（FBG）水平。在 Morris 水迷宫实验中，运动还显著缩短了糖尿病动物模型的逃避潜伏期，增加了平台穿越次数，提高了目标象限停留时间的百分比，延长了在目标象限停留的时间，并提高了游泳速度。次要结局指标的荟萃分析表明，运动可有效减少 Aβ 沉积，减轻氧化应激，增强突触功能，抑制细胞凋亡和神经炎症，促进神经发生。运动是一种很有前途的非药物治疗方法，对糖尿病相关认知功能和神经保护具有积极影响。此外，本研究为进一步的临床前和临床试验提供了理论基础。
