静脉内对比增强超声的使用是否能提高胃癌 T 分期诊断的准确性？

Whether the use of intravenous contrast-enhanced ultrasound can improve the accuracy of T stage diagnosis of gastric cancer?

机构信息

Ultrasound Medical Center, Lanzhou University Second Hospital, Lanzhou, China.

Gansu Province Clinical Research Center for Ultrasonography, Lanzhou, China.

出版信息

Clin Hemorheol Microcirc. 2024;86(4):433-440. doi: 10.3233/CH-231949.

DOI:10.3233/CH-231949

PMID:37980652

Abstract

OBJECTIVE

To explore whether the use of intravenous contrast-enhanced ultrasound (CEUS) can improve the diagnostic accuracy of T stage of gastric cancer on the basis of oral contrast-enhanced ultrasound (OCEUS).

METHODS

Eighty-one patients with gastric cancer who underwent preoperative CEUS. Criteria for T staging was AJCC Stage 8th Edition. To compare the diagnostic accuracy, sensitivity and specificity of OCEUS and CEUS for T staging of gastric cancer using pathological results as the gold standard.

RESULTS

There were differences in the diagnostic accuracy of T2 (P = 0.048), T3(P = 0.002) and T4 (P = 0.000) between OCEUS and CEUS. And there was no difference in diagnostic accuracy for T1 (P = 0.118). CEUS significantly improved diagnostic sensitivity and specificity in T3 (42.86% to 61.90% for sensitivity, 86.96% to 93.75% for specificity), and T4 (64.71% to 76.47% for sensitivity, 78.33% to 95.74% for specificity).

CONCLUSION

Compared with OCEUS, CEUS did improve the diagnostic accuracy of T2, T3, and T4 stages of gastric cancer.

摘要

目的

探讨静脉内超声造影（CEUS）能否在口服超声造影（OCEUS）的基础上提高胃癌 T 分期的诊断准确性。

方法

对 81 例术前接受 CEUS 的胃癌患者进行回顾性研究。采用第 8 版 AJCC 分期作为 T 分期标准。以病理结果为金标准，比较 OCEUS 和 CEUS 对胃癌 T 分期的诊断准确性、敏感性和特异性。

结果

OCEUS 和 CEUS 在 T2（P=0.048）、T3（P=0.002）和 T4（P=0.000）的诊断准确性方面存在差异。而在 T1（P=0.118）的诊断准确性方面无差异。CEUS 显著提高了 T3（敏感性从 42.86%提高到 61.90%，特异性从 86.96%提高到 93.75%）和 T4（敏感性从 64.71%提高到 76.47%，特异性从 78.33%提高到 95.74%）的诊断敏感性和特异性。