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采用二维超声胃肠充盈对比人工智能算法在胃癌临床诊断中的应用。

Adoption of Two-Dimensional Ultrasound Gastrointestinal Filling Contrast on Artificial Intelligence Algorithm in Clinical Diagnosis of Gastric Cancer.

机构信息

Department of Ultrasound Medicine, Wenjiang District People's Hospital, Chengdu, 611130 Sichuan, China.

出版信息

Comput Math Methods Med. 2022 Apr 30;2022:7385344. doi: 10.1155/2022/7385344. eCollection 2022.

Abstract

This research was aimed to explore the value of gastrointestinal filling contrast-enhanced ultrasound (CEUS) and computed tomography (CT-)-enhanced scanning based on artificial intelligence (AI) algorithm in the evaluation of gastric cancer staging. 102 patients with gastric cancer were selected as the research objects. All of them underwent CEUS of gastrointestinal filling and 64-slice spiral CT before surgery. In addition, an improved mean shift algorithm was proposed based on differential optical flow and deep convolutional neural network (D-CNN), which was applied in image processing. The predicted positive rate (PPR), sensitivity, specificity, and accuracy of gastric cancer in different stages by CEUS and CT were calculated using pathological diagnosis results as the gold standard. 17 patients with T1 stage, 41 patients with T2-T3 stage, and 35 patients with T4 stage were detected by CEUS. 13 patients with T1 stage, 34 patients with T2-T3 stage, and 30 patients with T4 stage were detected by CT enhanced examination. The PPRs of CEUS for T1, T2-T3, and T4 stages of gastric cancer were higher than those of CT enhanced ( < 0.05). The PPR of CEUS for N0 staging of gastric cancer was higher than that of CT enhanced ( < 0.05), and it for N3 staging of gastric cancer was lower than that of CT enhanced ( < 0.05). From the analysis of M staging of gastric cancer, the PPRs of CEUS for M0 and M1 staging of gastric cancer were not statistically different from the PPRs of CT enhanced ( > 0.05). The sensitivity (95.6%), specificity (81.82%), and accuracy (94.12%) of CEUS in assessing resectability were significantly higher than those of CT enhancement (89.01%, 63.67%, and 86.27%, respectively), and the differences were statistically significant ( < 0.05). In summary, CEUS gastrointestinal filling based on the D-CNN algorithm could better improve the display rate of the tissue lesions around the stomach. It also helped to judge the lesion progress, the depth of infiltration, and lymph node metastasis of the lesion. In addition, it had excellent performance in evaluating the resectability of gastric cancer before surgery and had clinical promotion value.

摘要

本研究旨在探讨基于人工智能(AI)算法的胃肠道充盈对比增强超声(CEUS)和计算机断层扫描(CT)增强扫描在胃癌分期评估中的价值。选取 102 例胃癌患者作为研究对象,所有患者均在术前进行胃肠道充盈 CEUS 和 64 层螺旋 CT 检查。此外,基于差分光学流和深度卷积神经网络(D-CNN)提出了一种改进的均值漂移算法,并应用于图像处理。以病理诊断结果为金标准,计算不同分期胃癌的 CEUS 和 CT 预测阳性率(PPR)、敏感度、特异度和准确率。CEUS 检测到 T1 期 17 例、T2-T3 期 41 例、T4 期 35 例,CT 增强检查检测到 T1 期 13 例、T2-T3 期 34 例、T4 期 30 例。CEUS 对胃癌 T1、T2-T3 和 T4 期的 PPR 均高于 CT 增强(<0.05)。CEUS 对胃癌 N0 期的 PPR 高于 CT 增强(<0.05),对胃癌 N3 期的 PPR 低于 CT 增强(<0.05)。从胃癌 M 分期分析,CEUS 对胃癌 M0 和 M1 期的 PPR 与 CT 增强无统计学差异(>0.05)。CEUS 评估可切除性的敏感度(95.6%)、特异度(81.82%)和准确率(94.12%)明显高于 CT 增强(分别为 89.01%、63.67%和 86.27%),差异有统计学意义(<0.05)。综上所述,基于 D-CNN 算法的 CEUS 胃肠道充盈可更好地提高胃周围组织病变的显示率,有助于判断病变进展、病变浸润深度和淋巴结转移,对术前评估胃癌的可切除性具有优异的性能,具有临床推广价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b93/9078808/db212b7b4739/CMMM2022-7385344.001.jpg

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