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隐球菌病:免疫酶法(酶联免疫吸附测定)血清学诊断(作者译)

[Cryptococcosis: serodiagnosis by immunoenzymology (ELISA) (author's transl)].

作者信息

Desgeorges P T, Ambroise-Thomas P, Goullier A

出版信息

Nouv Presse Med. 1979 Mar 17;8(13):1055-6.

PMID:379809
Abstract

For the first time ELISA test was applied for the human cryptococcosis serodiagnosis. We have used the somatic and metabolic antigene extracted from culture of Cryptococcus neoformans. It seems that metabolic antigenosis more specific and more actif. For two cryptococcosis conformated cases (9 sera), ELISA test was always and intensely positive and, in one case after curative treatment, we have seen an importante antibodies decrease. If this first results were confirmated, the ELISA test should give some new perspectives for the sero diagnosis of the cryptococcosis and for the survey of the treatment, that was until now in practice unrealizable.

摘要

首次将酶联免疫吸附测定(ELISA)试验应用于人类隐球菌病的血清学诊断。我们使用了从新型隐球菌培养物中提取的菌体和代谢抗原。代谢抗原似乎更具特异性且活性更强。对于两例确诊的隐球菌病病例(9份血清),ELISA试验始终呈强阳性,并且在一例经治疗康复的病例中,我们看到抗体显著减少。如果这些初步结果得到证实,ELISA试验应为隐球菌病的血清学诊断和治疗监测提供一些新的前景,而这在目前的实践中是无法实现的。

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