Zhao Lingyun, Wu Qingze, Long Yiying, Qu Qirui, Qi Fang, Liu Li, Zhang Liang, Ai Kun
College of Acupuncture, Tuina and Rehabilitation, Hunan University of Chinese Medicine, Changsha, China.
Hunan Traditional Chinese Medical College, Zhuzhou, China.
J Drug Target. 2024 Dec;32(1):1-20. doi: 10.1080/1061186X.2023.2284097. Epub 2024 Jan 12.
Vascular neogenesis, an early event in the development of rheumatoid arthritis (RA) inflammation, is critical for the formation of synovial vascular networks and plays a key role in the progression and persistence of chronic RA inflammation. microRNAs (miRNAs), a class of single-stranded, non-coding RNAs with approximately 21-23 nucleotides in length, regulate gene expression by binding to the 3' untranslated region (3'-UTR) of specific mRNAs. Increasing evidence suggests that miRNAs are differently expressed in diseases associated with vascular neogenesis and play a crucial role in disease-related vascular neogenesis. However, current studies are not sufficient and further experimental studies are needed to validate and establish the relationship between miRNAs and diseases associated with vascular neogenesis, and to determine the specific role of miRNAs in vascular development pathways. To better treat vascular neogenesis in diseases such as RA, we need additional studies on the role of miRNAs and their target genes in vascular development, and to provide more strategic references. In addition, future studies can use modern biotechnological methods such as proteomics and transcriptomics to investigate the expression and regulatory mechanisms of miRNAs, providing a more comprehensive and in-depth research basis for the treatment of related diseases such as RA.
血管新生是类风湿性关节炎（RA）炎症发展过程中的早期事件，对于滑膜血管网络的形成至关重要，并且在慢性RA炎症的进展和持续中起关键作用。微小RNA（miRNA）是一类单链非编码RNA，长度约为21 - 23个核苷酸，通过与特定mRNA的3'非翻译区（3'-UTR）结合来调节基因表达。越来越多的证据表明，miRNA在与血管新生相关的疾病中表达不同，并在疾病相关的血管新生中起关键作用。然而，目前的研究还不够充分，需要进一步的实验研究来验证和确立miRNA与血管新生相关疾病之间的关系，并确定miRNA在血管发育途径中的具体作用。为了更好地治疗RA等疾病中的血管新生，我们需要对miRNA及其靶基因在血管发育中的作用进行更多研究，并提供更多的策略参考。此外，未来的研究可以使用蛋白质组学和转录组学等现代生物技术方法来研究miRNA的表达和调控机制，为治疗RA等相关疾病提供更全面、深入的研究基础。
