Nabavizadeh Ali, Bagley Stephen J
Department of Radiology, Hospital of the University of Pennsylvania, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania.
Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania.
Clin Cancer Res. 2024 Jan 17;30(2):255-256. doi: 10.1158/1078-0432.CCR-23-3027.
In this CCR Translations, we discuss pharmacologic ascorbate as a novel therapeutic for glioblastoma (GBM). Aberrant iron metabolism in GBM can be assessed noninvasively by MRI and exploited to potentially improve the efficacy of chemoradiotherapy. We contextualize the study's results and discuss the next steps to further develop this paradigm. See related article by Petronek et al., p. 283.
在本期《癌症细胞报告》翻译中，我们讨论了药理学维生素C作为胶质母细胞瘤（GBM）的一种新型治疗方法。GBM中异常的铁代谢可以通过磁共振成像（MRI）进行无创评估，并有可能利用它来提高放化疗的疗效。我们将该研究结果置于背景中进行考量，并讨论进一步发展这一模式的后续步骤。见Petronek等人的相关文章，第283页。
