Department of Advanced Materials Engineering, Chung-Ang University, Anseong, 17546, Republic of Korea.
Department of Intelligence Energy and Industry, Chung-Ang University, Seoul, 06974, Republic of Korea.
Adv Healthc Mater. 2024 Feb;13(5):e2302797. doi: 10.1002/adhm.202302797. Epub 2023 Nov 29.
Chronic wounds represent a major health risk for diabetic patients. Regeneration of such wounds requires regular medical treatments over periods that can extend for several months or more. Schemes for monitoring the healing process can provide important feedback to the patient and caregiver. Although qualitative indicators such as malodor or fever can provide some indirect information, quantitative measurements of the wound bed have the potential to yield important insights. The work presented here introduces materials and engineering designs for a wireless system that captures spatio-temporal temperature and thermal transport information across the wound continuously throughout the healing process. Systematic experimental and computational studies establish the materials aspects and basic capabilities of this technology. In vivo studies reveal that both the temperature and the changes in this quantity offer information on wound status, with indications of initial exothermic reactions and mechanisms of scar tissue formation. Bioresorbable materials serve as the foundations for versions of this device that create possibilities for monitoring on and within the wound site, in a way that bypasses the risks of physical removal.
慢性伤口是糖尿病患者的主要健康风险。此类伤口的再生需要定期进行医疗治疗，持续时间可能长达数月甚至更长时间。监测愈合过程的方案可以为患者和护理人员提供重要的反馈。虽然恶臭或发热等定性指标可以提供一些间接信息，但对伤口床的定量测量有可能提供重要的见解。本文介绍了一种无线系统的材料和工程设计，该系统可在愈合过程中连续捕获伤口的时空温度和热传递信息。系统的实验和计算研究确立了这项技术的材料方面和基本功能。体内研究表明，温度及其变化都提供了伤口状况的信息，表明存在初始放热反应和疤痕组织形成的机制。可生物吸收的材料为该设备的版本奠定了基础，为在伤口部位内外进行监测创造了可能性，从而避免了物理移除的风险。
