Hubei Key Laboratory of Industrial Microbiology, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan, Hubei 430068, China.
Hubei Key Laboratory of Industrial Microbiology, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan, Hubei 430068, China.
Food Res Int. 2023 Dec;174(Pt 1):113566. doi: 10.1016/j.foodres.2023.113566. Epub 2023 Oct 10.
The rapid advancement of nanotechnology has opened up new avenues for applications in all stages of the food industry. Over the past decade, extensive research has emphasized that when nanoparticles (NPs) enter organisms, they spontaneously adsorbed biomolecules, leading to the formation of biocorona. This paper provided a detailed review of the process of biocorona formation in the food industry, including their classification and influencing factors. Additionally, various characterization methods to investigated the morphology and structure of biocoronas were introduced. As a real state of food industry nanoparticles in biological environments, the biocorona causes structural transformations of biomolecules bound to NPs, thus affecting their fate in the body. It can either promote or inhibit enzyme activity in the human environment, and may also positively or negatively affect the cellular uptake and toxicity of NPs. Since NPs present in the food industry will inevitably enter the human body, further investigations on biocoronas will offer valuable insights and perspectives on the safety of incorporating more NPs into the food industry.
纳米技术的快速发展为食品工业的各个阶段的应用开辟了新途径。在过去的十年中，大量研究强调，当纳米颗粒（NPs）进入生物体时，它们会自发吸附生物分子，从而形成生物冠。本文详细回顾了食品工业中生物冠形成的过程，包括其分类和影响因素。此外，还介绍了各种用于研究生物冠形态和结构的表征方法。作为生物环境中真正的纳米颗粒，生物冠导致与 NPs 结合的生物分子发生结构转变，从而影响它们在体内的命运。它可以促进或抑制人类环境中的酶活性，也可能对 NPs 的细胞摄取和毒性产生积极或消极的影响。由于食品工业中存在的 NPs 不可避免地会进入人体，因此对生物冠的进一步研究将为将更多 NPs 纳入食品工业的安全性提供有价值的见解和观点。
