沙特阿拉伯吉达市一家初级医疗保健中心2型糖尿病患者糖化血红蛋白（HbA1c）水平与血脂谱的相关性：一项回顾性横断面研究
Correlation of HbA1c Level with Lipid Profile in Type 2 Diabetes Mellitus Patients Visiting a Primary Healthcare Center in Jeddah City, Saudi Arabia: A Retrospective Cross-Sectional Study.
作者信息
Sharahili Abdulaziz Yahya, Mir Shabir Ahmad, ALDosari Sahar, Manzar Md Dilshad, Alshehri Bader, Al Othaim Ayoub, Alghofaili Fayez, Madkhali Yahya, Albenasy Kamal Shaker, Alotaibi Jazi S
机构信息
Department of Medical Laboratory Sciences, College of Applied Medical Science, Majmaah University, Al Majmaah 11952, Saudi Arabia.
Health and Basic Sciences Research Center, Majmaah University, Al Majmaah 11952, Saudi Arabia.
出版信息
Diseases. 2023 Oct 31;11(4):154. doi: 10.3390/diseases11040154.
INTRODUCTION
Type 2 diabetes mellitus (T2DM) patients are at high risk of dyslipidemia, which in turn is associated with macrovascular diseases, such as heart diseases and stroke, and microvascular diseases, such as neuropathy and nephropathy. There are contradictory findings in the literature regarding the relationship between glycated hemoglobin (HbA1c) and the lipid profile among T2DM patients. This study was performed to investigate the association between HbA1c level and the lipid profile in elderly T2DM patients at a primary care hospital in Jeddah City, Saudi Arabia.
METHODS
This study is a retrospective cross-sectional study conducted at the Prince Abdul Majeed Healthcare Center (PAMHC) in Jeddah, Saudi Arabia. The sociodemographic and clinical data of the T2DM patients who had visited the PAMHC from 1 January 2020 to 31 December 2021, were collected from the data registry of the PAMHC and analyzed for publication.
RESULTS
The study included a total of 988 T2DM patients (53.3% male). Of the participants, 42.9% were aged between 55 and 64 years. Dyslipidemia parameters were presented as high LDL-c (in 60.3% cases), low HDL-c (in 39.8% cases), high triglycerides (in 34.9% cases), and high total cholesterol (in 34.8% cases). The correlation of HbA1c with total cholesterol (TC) and triglycerides (TGs) was positively significant, thereby highlighting the important link between glycemic control and dyslipidemia. A mean increase of 4.88 mg/dL and 3.33 mmHg in TG level and diastolic blood pressure, respectively, was associated with the male gender, in comparison to the female gender. However, the male gender was significantly associated with the reduction in the mean cholesterol level, BMI, HbA1c, HDL-c, and LDL-c by 11.49 mg/dL, 1.39 kg/m, 0.31%, 7.47 mg/dL, and 5.6 mg/dL, respectively, in comparison to the female gender.
CONCLUSIONS
The results of this study show that HbA1c was significantly associated with cholesterol and triglyceride levels in the T2DM patients included in the study. Our findings highlight the important relationship between glycemic control and dyslipidemia.
引言
2型糖尿病（T2DM）患者发生血脂异常的风险很高，而血脂异常又与大血管疾病（如心脏病和中风）以及微血管疾病（如神经病变和肾病）相关。关于糖化血红蛋白（HbA1c）与T2DM患者血脂谱之间的关系，文献中有相互矛盾的研究结果。本研究旨在调查沙特阿拉伯吉达市一家基层医疗医院老年T2DM患者的HbA1c水平与血脂谱之间的关联。
方法
本研究是在沙特阿拉伯吉达市阿卜杜勒·马吉德王子医疗中心（PAMHC）进行的一项回顾性横断面研究。收集了2020年1月1日至2021年12月31日期间到PAMHC就诊的T2DM患者的社会人口统计学和临床数据，并从PAMHC的数据登记处进行分析以供发表。
结果
该研究共纳入988例T2DM患者（男性占53.3%）。参与者中，42.9%的年龄在55至64岁之间。血脂异常参数表现为高LDL-c（60.3%的病例）、低HDL-c（39.8%的病例）、高甘油三酯（34.9%的病例）和高总胆固醇（34.8%的病例）。HbA1c与总胆固醇（TC）和甘油三酯（TGs）的相关性呈显著正相关，从而突出了血糖控制与血脂异常之间的重要联系。与女性相比，男性的TG水平平均升高4.88 mg/dL，舒张压平均升高3.33 mmHg。然而，与女性相比，男性的平均胆固醇水平、BMI、HbA1c、HDL-c和LDL-c分别显著降低11.49 mg/dL、1.39 kg/m²、0.31%、7.47 mg/dL和5.6 mg/dL。
结论
本研究结果表明，在纳入研究的T2DM患者中，HbA1c与胆固醇和甘油三酯水平显著相关。我们的研究结果突出了血糖控制与血脂异常之间的重要关系。
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