Moroff S D, Hurvitz A I, Peterson M E, Saunders L, Noone K E
Vet Immunol Immunopathol. 1986 Nov;13(3):181-8. doi: 10.1016/0165-2427(86)90071-1.
Two shar-pei puppies examined because of signs of sinopulmonary disease, one of which also had skin disease, had deficient IgA concentrations. Deficient serum IgA concentrations also were confirmed in 30 of 39 (76.9%) clinically normal adult dogs in two colonies of shar-peis. Both courses of disease--sinopulmonary signs and chronic skin disease and a benign clinical course--have been reported in human patients with IgA deficiency. Thus, the shar-pei might be an appropriate model for studying the immunopathology of IgA deficiency in man.
两只沙皮幼犬因出现鼻窦肺部疾病症状接受检查，其中一只还患有皮肤病，其IgA浓度不足。在两个沙皮犬群体中，39只临床正常的成年犬中有30只（76.9%）也被证实血清IgA浓度不足。IgA缺乏的人类患者曾报告过两种病程——鼻窦肺部症状和慢性皮肤病以及良性临床病程。因此，沙皮犬可能是研究人类IgA缺乏免疫病理学的合适模型。
