Transtimulation Research Inc, Oklahoma City, OK, USA.
Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor MI, USA.
Expert Rev Gastroenterol Hepatol. 2023 Dec;17(12):1221-1232. doi: 10.1080/17474124.2023.2288156. Epub 2024 Jan 17.
Gastrointestinal motility disorders are highly prevalent without satisfactory treatment. noninvasive electrical neuromodulation is an emerging therapy for treating various gastrointestinal motility disorders.
In this review, several emerging noninvasive neuromodulation methods are introduced, including transcutaneous auricular vagal nerve stimulation, percutaneous auricular vagal nerve stimulation, transcutaneous cervical vagal nerve stimulation, transcutaneous electrical acustimulation, transabdominal interference stimulation, tibial nerve stimulation, and translumbosacral neuromodulation therapy. Their clinical applications in the most common gastrointestinal motility are discussed, including gastroesophageal reflux disease, functional dyspepsia, gastroparesis, functional constipation, irritable bowel syndrome, and fecal incontinence. PubMed database was searched from 1995 to June 2023 for relevant articles in English.
Noninvasive neuromodulation is effective and safe in improving both gastrointestinal symptoms and dysmotility; it can be used when pharmacotherapy is ineffective. Future directions include refining the methodology, improving device development and understanding mechanisms of action.
胃肠动力障碍的发病率很高，但治疗效果并不理想。非侵入性电神经调节是一种新兴的治疗各种胃肠动力障碍的方法。
本文介绍了几种新兴的非侵入性神经调节方法，包括经皮耳迷走神经刺激、经皮耳迷走神经刺激、经皮颈迷走神经刺激、经皮电声刺激、经腹干扰刺激、胫神经刺激和腰骶神经调节治疗。讨论了它们在最常见的胃肠动力障碍中的临床应用，包括胃食管反流病、功能性消化不良、胃轻瘫、功能性便秘、肠易激综合征和粪便失禁。检索了 1995 年至 2023 年 6 月期间发表在英文文献中的相关文章，使用 PubMed 数据库。
非侵入性神经调节在改善胃肠道症状和运动障碍方面是有效和安全的；当药物治疗无效时，可以使用。未来的方向包括完善方法学、改进设备开发和了解作用机制。
