Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Emerg Microbes Infect. 2024 Dec;13(1):2287118. doi: 10.1080/22221751.2023.2287118. Epub 2024 Jan 11.
This review gives an overview of the protective role of CD8 T cells in SARS-CoV-2 infection. The cross-reactive responses intermediated by CD8 T cells in unexposed cohorts are described. Additionally, the relevance of resident CD8 T cells in the upper and lower airway during infection and CD8 T-cell responses following vaccination are discussed, including recent worrisome breakthrough infections and variants of concerns (VOCs). Lastly, we explain the correlation between CD8 T cells and COVID-19 severity. This review aids in a deeper comprehension of the association between CD8 T cells and SARS-CoV-2 and broadens a vision for future exploration.
本文综述了 CD8 T 细胞在 SARS-CoV-2 感染中的保护作用。描述了未暴露人群中 CD8 T 细胞介导的交叉反应性应答。此外，还讨论了感染期间上呼吸道和下呼吸道中驻留 CD8 T 细胞以及接种疫苗后的 CD8 T 细胞反应的相关性，包括最近令人担忧的突破性感染和关注的变异株（VOCs）。最后，我们解释了 CD8 T 细胞与 COVID-19 严重程度之间的相关性。本文有助于更深入地理解 CD8 T 细胞与 SARS-CoV-2 的关联，并为未来的探索提供了更广阔的视野。
