Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
National Clinical Research Center for Kidney Disease, Guangzhou, China.
J Cachexia Sarcopenia Muscle. 2024 Feb;15(1):198-207. doi: 10.1002/jcsm.13366. Epub 2023 Nov 22.
We aimed to quantify the association of handgrip strength and self-reported walking pace with incident Parkinson's disease (PD) in the general population.
A total of 419 572 participants (54.1% females, mean age: 56.1 years [SD, 8.2]) without prior PD were included from UK Biobank. Handgrip strength was assessed by dynamometer. Walking pace was self-reported as slow, average or brisk. The study outcome was incident PD, determined by self-report data, hospital admission records or death records.
The mean handgrip strength was 23.5 (SD, 6.3) and 39.6 (SD, 8.9) kg for females and males, respectively. A total of 33 645 (8.0%), 221 682 (52.8%) and 164 245 (39.2%) participants reported slow, average and brisk walking pace, respectively. Over a median follow-up duration of 12.5 years, 2152 participants developed incident PD. When handgrip strength was assessed as sex-specific tertiles, compared with those in the third tertile, the adjusted hazard ratios (HRs) (95% confidence interval [CI]) of incident PD for participants in the second and first tertiles were 1.23 (1.09-1.39) and 1.60 (1.42-1.79), respectively. Compared with brisk walking pace, average (HR, 1.33; 95% CI: 1.20-1.47) or slow (HR, 1.84; 95% CI: 1.57-2.15) walking pace was associated with a higher risk of incident PD. A lower grip strength (Tertiles 1 and 2) and an average/slow walking pace accounted for 23.8% and 19.9% of PD cases, respectively. When handgrip strength and walking pace were considered together, the highest risk of incident PD was observed in participants with both lowest handgrip strength and slow walking pace (HR, 2.89; 95% CI: 2.30-3.64). Genetic risks of PD did not significantly modify the relation of handgrip strength (P for interaction = 0.371) or walking pace (P for interaction = 0.082) with new-onset PD.
Low handgrip strength and slow walking pace were significantly associated with a higher risk of incident PD, regardless of the individuals' genetic risk profile.
我们旨在量化握力和自我报告的行走速度与普通人群中帕金森病（PD）发病的关联。
共纳入来自英国生物银行的 419572 名（54.1%为女性，平均年龄 56.1 岁[标准差 8.2]）无 PD 病史的参与者。握力通过测力计进行评估。行走速度自我报告为慢、中、快。研究结果为 PD 的新发病例，通过自我报告数据、住院记录或死亡记录确定。
女性和男性的平均握力分别为 23.5（标准差 6.3）和 39.6（标准差 8.9）kg。分别有 33645（8.0%）、221682（52.8%）和 164245（39.2%）名参与者报告行走速度较慢、中等和较快。中位随访 12.5 年后，2152 名参与者发生 PD 新发病例。当握力按性别分为三分类时，与第三分类相比，第二和第一分类参与者的 PD 发病调整后的风险比（HR）（95%置信区间[CI]）分别为 1.23（1.09-1.39）和 1.60（1.42-1.79）。与快步行走速度相比，中速（HR，1.33；95%CI：1.20-1.47）或慢速（HR，1.84；95%CI：1.57-2.15）行走速度与 PD 新发风险增加相关。较低的握力（Tertiles 1 和 2）和中速/慢速行走速度分别占 PD 病例的 23.8%和 19.9%。当同时考虑握力和行走速度时，握力最低且行走速度最慢的参与者 PD 新发风险最高（HR，2.89；95%CI：2.30-3.64）。PD 的遗传风险并不能显著改变握力（交互作用 P=0.371）或行走速度（交互作用 P=0.082）与新发 PD 之间的关系。
无论个体的遗传风险状况如何，较低的握力和较慢的行走速度与 PD 新发风险的增加显著相关。
