握力、遗传易感性与帕金森病发病：英国生物银行的一项前瞻性队列研究
Grip strength, genetic predisposition, and Incident Parkinson's disease: a prospective cohort study in the UK Biobank.
作者信息
Hu Wei, Zhao Chun-Hua, Huang Yue-Qing, Liu Bao-Peng, Jia Cun-Xian
机构信息
Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
Medical Big Data Center, Department of General Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Nanjing Medical University, No. 26, Daoqian Street, Suzhou, 215001, Jiangsu, China.
出版信息
NPJ Parkinsons Dis. 2024 Oct 21;10(1):191. doi: 10.1038/s41531-024-00810-2.
To examine the association and modifiable risk factors between grip strength (GS) and Parkinson's disease (PD) incidence considering genetic factors, a total of 411,648 individuals without PD at baseline from the UK Biobank were included. GS was measured by a hydraulic dynamometer. The polygenic risk score assessed the genetic predisposition. Multivariable Cox regression models were performed. During a median follow-up of 12.3 years, 2409 individuals developed PD. Compared with those with high GS, low-GS individuals had a 58.5% increased risk of PD (42.7%-76.1%), and 16.3% of this excess risk could be explained by adjusted risk factors. Low GS and high genetic predisposition contribute to the highest PD risk in an additive interaction. We observed that low GS was associated with higher PD incidence, particularly among individuals with high genetic predisposition. In addition to enhancing GS, interventions targeting risk factors (e.g., unhealthy lifestyles) might also reduce the excess risk.
为了在考虑遗传因素的情况下研究握力（GS）与帕金森病（PD）发病率之间的关联及可改变的风险因素，我们纳入了英国生物银行中411,648名基线时无PD的个体。通过液压测力计测量握力。多基因风险评分评估遗传易感性。进行多变量Cox回归模型分析。在中位随访12.3年期间，有2409人患上了PD。与高握力者相比，低握力者患PD的风险增加了58.5%（42.7%-76.1%），调整后的风险因素可解释这一额外风险的16.3%。低握力和高遗传易感性在相加相互作用中导致最高的PD风险。我们观察到低握力与较高的PD发病率相关，尤其是在遗传易感性高的个体中。除了增强握力外，针对风险因素（如不健康的生活方式）的干预措施也可能降低额外风险。
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