Jasim S, Tjälve H
Acta Pharmacol Toxicol (Copenh). 1986 Sep;59(3):204-8. doi: 10.1111/j.1600-0773.1986.tb00155.x.
Oral administration of zinc pyridinethione together with 63Ni2+ or 109Cd2+ to mice resulted in increased levels of these metals in several tissues in comparison with animals given the metals alone. The disposition of the 63Ni2+ was affected more than the disposition of the 109Cd2+. Increased urinary excretion of the metals was also induced by the zinc pyridinethione. Determinations of chloroform:water partition coefficients showed that lipophilic complexes are formed at equilibrations between Ni2+ or Cd2+ and zinc pyridinethione. A facilitated penetration of the lipophilic metal complexes through the cellular membranes in the gastrointestinal tract and in other tissues is probably important for the observed results. Our data suggest that effects on the disposition of metals may play a role for the toxicity of zinc pyridinethione.
给小鼠口服吡啶硫酮锌并同时给予⁶³Ni²⁺或¹⁰⁹Cd²⁺，与单独给予这些金属的动物相比，几种组织中这些金属的含量增加。⁶³Ni²⁺的分布比¹⁰⁹Cd²⁺的分布受影响更大。吡啶硫酮锌还诱导了这些金属尿排泄增加。氯仿：水分配系数的测定表明，在Ni²⁺或Cd²⁺与吡啶硫酮锌之间达到平衡时会形成亲脂性络合物。亲脂性金属络合物通过胃肠道和其他组织中的细胞膜的促进渗透可能对观察到的结果很重要。我们的数据表明，对金属分布的影响可能在吡啶硫酮锌的毒性中起作用。
