Language Sciences, Department of Human Sciences, Graduate School of Humanities, Tokyo Metropolitan University, Hachioji, Tokyo, Japan; Research Center for Language, Brain and Genetics, Tokyo Metropolitan University, Hachioji, Tokyo, Japan.
Department of Pediatrics, Faculty of Medicine, Kagawa University, Kagawa, Japan.
Neuroimage. 2023 Dec 15;284:120465. doi: 10.1016/j.neuroimage.2023.120465. Epub 2023 Nov 21.
Neural-activity-associated hemodynamic changes have been used to noninvasively measure brain function in the early developmental stages. However, the temporal changes in their hemodynamics are not always consistent with adults. Studies have not evaluated developmental changes for a long period using the same stimuli; therefore, this study examined the normalized relative changes in oxygenated hemoglobin (Δ[oxy-Hb]) in full-term infants and compared them with neonates up to 10 months of age during the administration of tactile vibration stimuli to their limbs using whole-head functional near-infrared spectroscopy. The time to peak of normalized Δ[oxy-Hb] was not affected by age. The amplitude of normalized Δ[oxy-Hb] showed an effect of age in broader areas, including sensorimotor-related but excluding supplementary motor area; the amplitude of normalized Δ[oxy-Hb] decreased the most in the 1-2-month-old group and later increased with development. We hypothesized that these results may reflect developmental changes in neural activity, vasculature, and blood oxygenation.
神经活动相关的血液动力学变化已被用于非侵入性地测量早期发育阶段的大脑功能。然而，它们的血液动力学的时间变化并不总是与成年人一致。研究尚未使用相同的刺激物对其进行长期的发育变化评估；因此，本研究使用全头功能近红外光谱检查了对其四肢进行触觉振动刺激时足月婴儿和最多 10 个月大的新生儿的氧合血红蛋白（Δ[oxy-Hb]）的归一化相对变化，并对其进行了比较。归一化 Δ[oxy-Hb]的峰值时间不受年龄影响。归一化 Δ[oxy-Hb]的幅度在更广泛的区域显示出年龄的影响，包括感觉运动相关区域，但不包括补充运动区；归一化 Δ[oxy-Hb]的幅度在 1-2 个月大的婴儿中下降最大，随后随着发育而增加。我们假设这些结果可能反映了神经活动、血管和血氧的发育变化。
