Llamas-Ramos Rocío, Sánchez-González Juan Luis, Alvarado-Omenat Jorge Juan, Sanz-Esteban Ismael, Serrano J Ignacio, Llamas-Ramos Inés
Department of Nursing and Physiotherapy, Universidad de Salamanca, 37007 Salamanca, Spain.
Instituto de Investigación Biomédica de Salamanca (IBSAL), 37007 Salamanca, Spain.
J Clin Med. 2025 May 29;14(11):3818. doi: 10.3390/jcm14113818.
Newborns' plasticity allows the brain to adapt and reorganize in response to external stimuli; therefore, tactile stimuli could generate brain changes. The objective of this study was to verify the feasibility of using fNIRS to measure the degree of brain oxygenation with tactile techniques in babies. Oxygenation was recorded continuously and bilaterally before, during, and after the interventions (massage protocol and Reflex Locomotion Therapy) with functional near-infrared spectroscopy in 11-week-old babies. Preliminary data suggested that the massage intervention decreased the activity bilaterally (first minute of the intervention) and then increased it bilaterally (second minute), where it continued to increase in the left hemisphere (third minute) before decreasing bilaterally (fourth minute). Finally, the activity continued to decrease in the right hemisphere but increased in the most dorsal area of the left hemisphere (fifth minute). For the Reflex Locomotion intervention, the activity substantially increased bilaterally (first minute of the intervention) and then decreased bilaterally, but more pronouncedly in the left hemisphere (second minute). Then, the activity decreased to pre-intervention values (third minute) and increased bilaterally again, but pronouncedly in the right hemisphere (fourth minute). In the fifth minute, the activity in the right hemisphere drastically decreased, but it increased in the left hemisphere. During the post-intervention resting period, in the massage intervention, the activity increased in the right hemisphere and in the most ventral part of the left hemisphere; in Reflex Locomotion Therapy, the activity decreased only in the left hemisphere. Both techniques achieve a potential increase in oxyhemoglobin concentration bilaterally during stimulation, but while the effects decrease with Reflex Locomotion Therapy, the effects are maintained with massage. More studies are needed to establish the neurophysiological basis of these therapies in pediatrics.
新生儿的可塑性使大脑能够对外界刺激做出适应和重组；因此，触觉刺激可能会引起大脑变化。本研究的目的是验证使用功能近红外光谱（fNIRS）通过触觉技术测量婴儿大脑氧合程度的可行性。在11周大的婴儿中，采用功能近红外光谱法在干预（按摩方案和反射性运动疗法）前、干预期间和干预后连续双侧记录氧合情况。初步数据表明，按摩干预使双侧活动先减少（干预的第一分钟），然后双侧增加（第二分钟），之后左半球持续增加（第三分钟），随后双侧减少（第四分钟）。最后，右半球活动持续减少，但左半球最背侧区域的活动增加（第五分钟）。对于反射性运动干预，活动在双侧大幅增加（干预的第一分钟），然后双侧减少，但在左半球更明显（第二分钟）。然后，活动降至干预前水平（第三分钟），并再次双侧增加，但在右半球更明显（第四分钟）。在第五分钟，右半球的活动急剧下降，但左半球的活动增加。在干预后的休息期，在按摩干预中，右半球以及左半球最腹侧部分的活动增加；在反射性运动疗法中，活动仅在左半球减少。两种技术在刺激过程中均使双侧氧合血红蛋白浓度有潜在增加，但反射性运动疗法的效果会降低，而按摩的效果会持续。需要更多研究来确立这些儿科疗法的神经生理学基础。
