Anderson H V, Zaatari G S, Roubin G S, Leimgruber P P, Gruentzig A R
Am Heart J. 1987 Jan;113(1):37-48. doi: 10.1016/0002-8703(87)90007-x.
Intracoronary delivery of argon laser energy was studied in eight anesthetized mongrel dogs. A No. 4.5 French single lumen catheter, with steerable guidewire and an optical fiber, was introduced through a Judkins-type femoral-coronary guiding catheter into three left anterior descending and eight left circumflex coronary arteries. A total of 65 laser energy exposures were made coaxially at 24 sites in the 11 arteries. At five sites, angiographically evident arterial perforation occurred with the first laser exposure, while at seven sites multiple laser exposures were made without angiographically evident perforation. All eight dogs remained hemodynamically stable, and were electively killed 5 +/- 1 hours following the procedure. Sections of myocardium from territories supplied by treated arteries demonstrated minimal or no pathology in 10 cases, while one territory had a small zone of early myocardial necrosis. This study suggests that standard coronary artery catheterization techniques can be used to introduce and position a steerable guidewire and an optical fiber in canine coronary arteries. Laser energy can repeatedly be delivered coaxially. Short-term deleterious effects may be reduced or eliminated, and exposure of blood elements to argon laser energy does not appear to create debris.
在八只麻醉的杂种狗身上研究了冠状动脉内输送氩激光能量的情况。通过一根Judkins型股-冠状动脉引导导管，将一根带有可操纵导丝和光纤的4.5法国号单腔导管插入三条左前降支冠状动脉和八条左旋支冠状动脉。在11条动脉的24个部位共同轴进行了65次激光能量照射。在五个部位，首次激光照射时出现了血管造影可见的动脉穿孔，而在七个部位进行了多次激光照射但未出现血管造影可见的穿孔。所有八只狗在血流动力学上均保持稳定，并在手术后5±1小时被选择性处死。来自接受治疗动脉供血区域的心肌切片在10例中显示出极少或无病理改变，而一个区域有一小片早期心肌坏死区。本研究表明，标准冠状动脉插管技术可用于在犬冠状动脉中引入和定位可操纵导丝和光纤。激光能量可反复同轴输送。短期有害影响可能会减少或消除，并且血液成分暴露于氩激光能量似乎不会产生碎片。
