Ben-Shachar G, Sivakoff M C, Bernard S L, Dahms B B, Riemenschneider T A
Am Heart J. 1985 Jul;110(1 Pt 1):65-70. doi: 10.1016/0002-8703(85)90516-2.
Fresh isolated myocardial, elastic-arterial, and valvular tissues from seven canine hearts were irradiated by argon laser. Irradiation was transmitted through 300 and 400 micron flexible quartz fiberoptic elements. Minimal power densities for vaporization of the myocardial, arterial, and valvular tissues were 80, 90, and 110 W/cm2, respectively, with maximal vaporization distances (fiberoptic tip to tissue) of 4 mm, 1 mm, and 1 mm, respectively. Irradiation of the valves at power densities approaching perforation caused contraction of the tissue. When tissue vaporization occurred, histologic examination of irradiated tissues showed a central crater surrounded by sequential layers of char, vaporization, and coagulation necrosis. These findings were common to all cardiac tissues. Additional findings unique to myocardium were a normal-appearing myocardial layer (skip-area), circumferential halo, and tissue clefts. Elastic arteries showed concentration of necrosis around the collagen and elastic fibers. Valvular damage was the most extensive and also included contraction of adjacent valvular tissue and endocardial sloughing.
取自七只犬心脏的新鲜分离心肌、弹性动脉和瓣膜组织接受了氩激光照射。照射通过300微米和400微米的柔性石英光纤元件进行传输。心肌、动脉和瓣膜组织汽化的最小功率密度分别为80、90和110W/cm²，最大汽化距离（光纤尖端到组织）分别为4毫米、1毫米和1毫米。以接近穿孔的功率密度照射瓣膜会导致组织收缩。当发生组织汽化时，照射组织的组织学检查显示中央有一个火山口，周围依次是炭化、汽化和凝固性坏死层。这些发现见于所有心脏组织。心肌特有的其他发现是外观正常的心肌层（跳跃区）、环形晕和组织裂隙。弹性动脉显示胶原和弹性纤维周围有坏死集中。瓣膜损伤最为广泛，还包括相邻瓣膜组织的收缩和心内膜脱落。
