Department of Nutrition and Food Hygiene, School of Public Health, Institute of Nutrition, Shanghai, People's Republic of China.
Department of Intensive Medicine, Kailuan General Hospital, Tangshan, People's Republic of China.
Clin Cardiol. 2024 Feb;47(2):e24119. doi: 10.1002/clc.24119. Epub 2023 Nov 23.
Although risk factors for mortality in individuals with cardiovascular diseases (CVD) have been reported, little is known regarding the association between the comprehensive cardiovascular health (CVH) index assessed by life's essential 8 (LE8) and the risk of mortality.
The aim of this study was to evaluate the CVH assessed by LE8 and risk of mortality in individuals with CVD.
A total of 1391 participants with CVD diagnosed before 2014 from the Kailuan cohort were included in the analysis. The CVH score ranged from 0 to 100 was assessed using the LE8 metrics (diet quality, physical activity, sleep health, cigarette smoking, body mass index, lipids, blood glucose, and blood pressure). Cox regression model was used to estimate the association between the CVH score and risk of all-cause mortality.
During a mean follow-up of 6.1 ± 1.5 years, 229 deaths occurred. The hazard ratio for all-cause mortality was 0.57 (95% confidence interval [CI]: 0.38, 0.84) in the highest quartiles compared with the lowest quartiles of CVH scores and 0.85 (95% CI: 0.75, 0.95) for each 10 points increment in CVH scores (p = .009), after adjustment for age, sex, CVD duration, social-economic status, alcohol consumption, inflammation, medicine use, and kidney function. We did not observe significant interactions between the CVH scores and age, sex, and duration of CVD diagnosis (p > .05 for all).
The CVH assessed by the LE8 metrics was associated with a lower risk of all-cause mortality in individuals with CVD.
尽管已有研究报道了心血管疾病（CVD）患者死亡的风险因素，但对于通过生命必需的 8 项（LE8）评估的综合心血管健康（CVH）指数与死亡风险之间的关系知之甚少。
本研究旨在评估通过 LE8 评估的 CVH 与 CVD 患者死亡风险之间的关系。
共纳入 1391 名于 2014 年前被诊断为 CVD 的患者进行分析。使用 LE8 指标（饮食质量、身体活动、睡眠健康、吸烟状况、体重指数、血脂、血糖和血压）评估 CVH 评分，范围为 0 至 100。Cox 回归模型用于评估 CVH 评分与全因死亡率之间的关系。
在平均 6.1±1.5 年的随访期间，有 229 例死亡。与 CVH 评分最低四分位相比，CVH 评分最高四分位的全因死亡率的风险比为 0.57（95%置信区间[CI]：0.38，0.84），CVH 评分每增加 10 分，全因死亡率的风险比为 0.85（95%CI：0.75，0.95）（p=0.009），校正年龄、性别、CVD 持续时间、社会经济地位、饮酒、炎症、药物使用和肾功能后。我们未观察到 CVH 评分与年龄、性别和 CVD 诊断持续时间之间存在显著交互作用（p均>0.05）。
通过 LE8 指标评估的 CVH 与 CVD 患者的全因死亡率降低相关。
