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营养基因组学:与食物偏好和易感性相关的单核苷酸多态性。

Nutrigenomics: SNPs correlated to Food Preferences and Susceptibilities.

机构信息

MAGI'S LAB, Rovereto (TN), Italy.

Department of Pharmaceutical Sciences, University of Perugia, Italy.

出版信息

Clin Ter. 2023 Nov-Dec;174(Suppl 2(6)):214-226. doi: 10.7417/CT.2023.2490.

Abstract

BACKGROUND

Nutrigenomics explores the intricate interplay between single nucleotide polymorphisms (SNPs), food preferences, and susceptibilities.

METHODS

This study delves into the influence of SNPs on food sensitivities, allergies, tyramine intolerance, and taste preferences. Genetic factors intricately shape physiological reactions to dietary elements, with polymorphisms contributing to diverse sensitivities and immune responses.

RESULTS

Tyramine intolerance, arising from metabolic inefficiencies, unveils genetic markers exerting influence on enzyme function. SNPs transcend genetic diversity by exerting substantial impact on food sensitivities/allergies, with specific variants correlating to heightened susceptibilities. Genes accountable for digesting food components play pivotal roles. Given the rising prevalence of food sensitivities/allergies, understanding genetic foundations becomes paramount. In the realm of taste and food preferences, SNPs sculpt perception and choice, yielding variances in taste perception and preferences for sweetness, bitterness, and umami. This genetic medley extends its reach to encompass wider health implications.

CONCLUSIONS

In this review article, we have focused on how polymorphisms wield significant sway over physiological responses, sensitivities, and dietary inclinations. Unraveling these intricate relationships illuminates the path to personalized nutrition, potentially revolutionizing tailored recommendations and interventions.

摘要

背景

营养基因组学探索了单核苷酸多态性(SNPs)、食物偏好和易感性之间的复杂相互作用。

方法

本研究深入探讨了 SNPs 对食物敏感性、过敏、酪胺不耐受和味觉偏好的影响。遗传因素错综复杂地影响着人体对膳食元素的生理反应,多态性导致了不同的敏感性和免疫反应。

结果

由于代谢效率低下而引起的酪胺不耐受,揭示了对酶功能有影响的遗传标记。SNP 通过对食物敏感性/过敏产生重大影响,超越了遗传多样性,特定的变体与更高的易感性相关。负责消化食物成分的基因起着关键作用。鉴于食物敏感性/过敏的发病率不断上升,了解遗传基础变得至关重要。在味觉和食物偏好方面,SNP 塑造了感知和选择,导致味觉感知和对甜味、苦味和鲜味的偏好存在差异。这种基因的混合也延伸到了更广泛的健康影响。

结论

在这篇综述文章中,我们重点关注了多态性如何对生理反应、敏感性和饮食倾向产生重大影响。揭示这些复杂的关系为个性化营养铺平了道路,有可能彻底改变个性化建议和干预措施。

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